A guide to the composition and functions of the extracellular matrix

NK Karamanos, AD Theocharis, Z Piperigkou… - The FEBS …, 2021 - Wiley Online Library
Extracellular matrix (ECM) is a dynamic 3‐dimensional network of macromolecules that
provides structural support for the cells and tissues. Accumulated knowledge clearly …

A comprehensive review on collagen type I development of biomaterials for tissue engineering: From biosynthesis to bioscaffold

IN Amirrah, Y Lokanathan, I Zulkiflee, MFMR Wee… - Biomedicines, 2022 - mdpi.com
Collagen is the most abundant structural protein found in humans and mammals, particularly
in the extracellular matrix (ECM). Its primary function is to hold the body together. The …

Memorable full-color circularly polarized luminescence from chiral co-assembled polymer films enabled by multipath transfer

G Zhang, Y Bao, M Pan, N Wang, X Cheng… - Science China …, 2023 - Springer
The modulation of circularly polarized luminescence (CPL) is of importance for display and
asymmetric chemical synthesis. However, the underlying mechanism of CPL transfer …

Cartilage-related collagens in osteoarthritis and rheumatoid arthritis: from pathogenesis to therapeutics

Z Ouyang, L Dong, F Yao, K Wang, Y Chen… - International Journal of …, 2023 - mdpi.com
Collagens serve essential mechanical functions throughout the body, particularly in the
connective tissues. In articular cartilage, collagens provide most of the biomechanical …

Collagen-based biocomposites inspired by bone hierarchical structures for advanced bone regeneration: Ongoing research and perspectives

D Qin, N Wang, XG You, AD Zhang, XG Chen… - Biomaterials …, 2022 - pubs.rsc.org
Bone is a hard-connective tissue composed of matrix, cells and bioactive factors with a
hierarchical structure, where the matrix is mainly composed of type I collagen and …

[HTML][HTML] Multivalent protein-drug conjugates–An emerging strategy for the upgraded precision and efficiency of drug delivery to cancer cells

N Porębska, K Ciura, A Chorążewska… - Biotechnology …, 2023 - Elsevier
With almost 20 million new cases per year, cancer constitutes one of the most important
challenges for public health systems. Unlike traditional chemotherapy, targeted anti-cancer …

Collagen biosynthesis, processing, and maturation in lung ageing

C Onursal, E Dick, I Angelidis, HB Schiller… - Frontiers in …, 2021 - frontiersin.org
In addition to providing a macromolecular scaffold, the extracellular matrix (ECM) is a critical
regulator of cell function by virtue of specific physical, biochemical, and mechanical …

Collagen-based hydrogels for the eye: A comprehensive review

D Rana, N Desai, S Salave, B Karunakaran, J Giri… - Gels, 2023 - mdpi.com
Collagen-based hydrogels have emerged as a highly promising platform for diverse
applications in ophthalmology, spanning from drug delivery systems to biomedical …

Tunnels for protein export from the endoplasmic reticulum

I Raote, V Malhotra - Annual review of biochemistry, 2021 - annualreviews.org
The functions of coat protein complex II (COPII) coats in cargo packaging and the creation of
vesicles at the endoplasmic reticulum are conserved in eukaryotic protein secretion …

Natural load-bearing protein materials

MJ Harrington, P Fratzl - Progress in Materials Science, 2021 - Elsevier
Biological tissues in animals generally consist an extracellular matrix often with cells
embedded in it. These materials are primarily comprised of different protein building blocks …