The last decade has witnessed enormous research focused on cationic polymers. Cationic
polymers are the subject of intense research as non-viral gene delivery systems, due to their …

Abstract Recently, United States Food and Drug Administration (FDA) and European
Commission (EC) approved Alnylam Pharmaceuticals' RNA interference (RNAi) therapeutic …

A key end goal of gene delivery research is to develop clinically relevant vectors that can be
used to combat elusive diseases such as AIDS. Despite promising engineering strategies …

Cationic lipids are one of the most widely used nonviral vectors for gene delivery and are
especially attractive because they can be easily synthesized and extensively characterized …

Nanomedicine is the manipulation of human biological systems at the molecular level using
nanoscale or nanostructured materials. Because nanoscale materials interact effectively …

Small interfering RNAs (siRNAs) technology has emerged as a promising potential
treatment for viral, genetic diseases and cancers. Despite the powerful therapeutic potential …

Biodegradable polymers provided the opportunity to explore beyond conventional drug
delivery and turned out to be the focus of current drug delivery. In spite of availability of …

The request of new materials, matching strict requirements to be applied in precision and
patient-specific medicine, is pushing for the synthesis of more and more complex block …

Within the field of gene therapy, there is a considerable need for the development of non-
viral vectors that are able to compete with the efficiency obtained by viral vectors, while …

Effective therapeutics against triple negative breast cancer (TNBC), which has no standard-
of-care therapy, needs to be developed urgently. Here we demonstrated a strategy of …