Diabetic retinopathy is a common complication of diabetes and remains the leading cause of
blindness among the working-age population. For decades, diabetic retinopathy was …

Age-associated chronic inflammation is characterized by unresolved and uncontrolled
inflammation with multivariable low-grade, chronic and systemic responses that exacerbate …

Complex genetic and physiological variations as well as environmental factors that drive
emergence of chromosomal instability, development of unscheduled cell death, skewed …

Twenty years after the proposal that pattern recognition receptors detect invasion by
microbial pathogens, the field of immunology has witnessed several discoveries that have …

The receptor for advanced glycation end-product (RAGE) is the signal transduction receptor
which senses a variety of signalling molecules including advanced glycation end products …

Abstract Silica nanoparticles (SiO 2 NPs) are extensively applied in various field, which
increased their health risks to humans. SiO 2 NPs were reported to enter into blood through …

Osteoarthritis (OA) is the most common age-related chronic and disabling joint disease.
Long considered to be a “wear and tear” disease, OA is now seen as a low-grade …

Although much progress is being made in understanding the molecular pathways in the
placenta that are involved in the pathophysiology of pregnancy-related disorders, a …

Inflammation is a complex and potentially life-threatening condition that involves the
participation of a variety of chemical mediators, signaling pathways, and cell types. The …

Abstract The Receptor for Advanced Glycation Endproducts [RAGE] is an evolutionarily
recent member of the immunoglobulin super-family, encoded in the Class III region of the …