A guide to membraneless organelles and their various roles in gene regulation

T Hirose, K Ninomiya, S Nakagawa… - … Reviews Molecular Cell …, 2023 - nature.com
Membraneless organelles (MLOs) are detected in cells as dots of mesoscopic size. By
undergoing phase separation into a liquid-like or gel-like phase, MLOs contribute to …

Mammalian stress granules and P bodies at a glance

CL Riggs, N Kedersha, P Ivanov… - Journal of cell …, 2020 - journals.biologists.com
Stress granules (SGs) and processing bodies (PBs) are membraneless ribonucleoprotein-
based cellular compartments that assemble in response to stress. SGs and PBs form …

[HTML][HTML] Molecular mechanisms of stress granule assembly and disassembly

S Hofmann, N Kedersha, P Anderson… - Biochimica et Biophysica …, 2021 - Elsevier
Stress granules (SGs) are membrane-less ribonucleoprotein (RNP)-based cellular
compartments that form in the cytoplasm of a cell upon exposure to various environmental …

MAPK-activated protein kinases: servant or partner?

N Ronkina, M Gaestel - Annual review of biochemistry, 2022 - annualreviews.org
Mitogen-activated protein kinase (MAPK)-activated protein kinases (MAPKAPKs) are
defined by their exclusive activation by MAPKs. They can be activated by classical and …

The stress granule transcriptome reveals principles of mRNA accumulation in stress granules

A Khong, T Matheny, S Jain, SF Mitchell, JR Wheeler… - Molecular cell, 2017 - cell.com
Stress granules are mRNA-protein assemblies formed from nontranslating mRNAs. Stress
granules are important in the stress response and may contribute to some degenerative …

Stress granules and processing bodies in translational control

P Ivanov, N Kedersha… - Cold Spring Harbor …, 2019 - cshperspectives.cshlp.org
Stress granules (SGs) and processing bodies (PBs) are non-membrane-enclosed RNA
granules that dynamically sequester translationally inactive messenger ribonucleoprotein …

Oncogenic RAS signaling promotes tumor immunoresistance by stabilizing PD-L1 mRNA

MA Coelho, S de Carné Trécesson, S Rana, D Zecchin… - Immunity, 2017 - cell.com
The immunosuppressive protein PD-L1 is upregulated in many cancers and contributes to
evasion of the host immune system. The relative importance of the tumor microenvironment …

A new phase of networking: the molecular composition and regulatory dynamics of mammalian stress granules

SR Millar, JQ Huang, KJ Schreiber, YC Tsai… - Chemical …, 2023 - ACS Publications
Stress granules (SGs) are cytosolic biomolecular condensates that form in response to
cellular stress. Weak, multivalent interactions between their protein and RNA constituents …

Inhibitory feedback control of NF-κB signalling in health and disease

JA Prescott, JP Mitchell, SJ Cook - Biochemical Journal, 2021 - portlandpress.com
Cells must adapt to changes in their environment to maintain cell, tissue and organismal
integrity in the face of mechanical, chemical or microbiological stress. Nuclear factor-κB (NF …

A central chaperone-like role for 14-3-3 proteins in human cells

D Segal, S Maier, GJ Mastromarco, WW Qian… - Molecular cell, 2023 - cell.com
3-3 proteins are highly conserved regulatory proteins that interact with hundreds of
structurally diverse clients and act as central hubs of signaling networks. However, how 14-3 …