Absorption, distribution, metabolism and excretion (ADME) studies represent a fundamental
step in the early stages of drug discovery. In particular, the absorption of orally administered …

The transdermal route of drugs has received increased attention in recent years due to
numerous advantages over the oral and injectable routes, such as avoidance of the hepatic …

Cell-free permeation systems are gaining interest in drug discovery and development as
tools to obtain a reliable prediction of passive intestinal absorption without the …

Topical drug delivery across the skin can offer many advantages, such as confer sustained
drug release, lower fluctuations in plasma drug levels, circumvent first-pass metabolism …

Franz diffusion cell was primarily used to evaluate the permeability and stability of
formulations such as topical (gels and creams) and transdermal (lipid nanoparticle …

Dermal and transdermal drug therapy is increasing in importance nowadays in drug
development. To completely utilize the potential of this administration route, it is necessary to …

Purpose The usefulness of the synthetic membrane, Strat-M™ as an alternative to human
and animal skins was evaluated by estimating the skin permeabilities of chemical …

Abstract (Trans) dermal drug therapy is gaining increasing importance in the modern drug
development. To fully utilize the potential of this route, it is important to optimize the delivery …

Tremendous progress has been made over the past few decades to develop skin substitutes
for the management of acute and chronic wounds. With the advent of tissue engineering and …

In vitro diffusive models are an important tool to screen the penetration ability of active
ingredients in various formulations. A reliable assessment of skin penetration enhancing …