In this review, we highlight the role of intratumoral heterogeneity, focusing on the clinical and
biological ramifications this phenomenon poses. Intratumoral heterogeneity arises through …

The recently uncovered key role of the peripheral and central nervous systems in controlling
tumorigenesis and metastasis has opened a new area of research to identify innovative …

Gut microbiota alterations have been described in several diseases with altered
gastrointestinal (GI) motility, and awareness is increasing regarding the role of the gut …

In addition to ghrelin's effects on appetite and adiposity, ghrelin signalling also plays crucial
roles in glucose and energy homeostasis, cardioprotection, muscle atrophy and bone …

Ghrelin is an octanoylated peptide that acts via its specific receptor, the growth hormone
secretagogue receptor type 1a (GHSR-1a), and regulates a vast variety of physiological …

Cachexia is a devastating complication of cancer and an important cause of morbidity and
mortality and can have a great effect on quality of life, and sense of self-esteem …

The only molecularly identified ghrelin receptor is the growth hormone secretagogue
receptor GHSR1a. Its natural ligand, ghrelin, is an acylated peptide whose unacylated …

The GH/IGF1 response of somatotropinomas to somatostatin analogues (SSA) is associated
with their pattern of somatostatin receptor (sst1-sst5) expression. Recently, we demonstrated …

Ghrelin, the endogenous ligand for the GH secretagogue receptor (GHSR), is a peptide
hormone with diverse physiological roles. Ghrelin regulates GH release, appetite and …

The dysregulation of the splicing process has emerged as a novel hallmark of metabolic and
tumor pathologies. In breast cancer (BCa), which represents the most diagnosed cancer …