Melanoma is the deadliest form of skin cancer and its incidence is rising, creating a costly
and significant clinical problem. Exposure to ultraviolet (UV) radiation, namely UVA (315 …

Thyroid cancer is an increasingly prevalent malignancy throughout the world. Management
guidelines for both thyroid nodules and thyroid cancer have been published and updated by …

The incidence of melanoma is increasing over the years with a still poor prognosis and the
lack of a cure able to guarantee an adequate survival of patients. Although the new immuno …

Melanoma is the foremost malignant cutaneous cancer and it is extremely resistant to
chemotherapy and radiotherapy. Curcumin is an active component of turmeric, the yellow …

Melanoma, the most aggressive skin cancer, is mainly treated with BRAF inhibitors or
immunotheareapy. However, most patients who initially responded to BRAF inhibitors or …

The notorious unresponsiveness of metastatic cutaneous melanoma to current treatment
strategies coupled with its increasing incidence constitutes a serious worldwide clinical …

The phosphatidylinositol 3-kinase/AKT/mammalian target of rapamycin (PI3K/AKT/mTOR)
pathway promotes melanoma tumor growth and survival while suppressing autophagy, a …

Although the global incidence of cutaneous melanoma is increasing, survival rates for
patients with metastatic disease remain< 10%. Novel treatment strategies are therefore …

The antitumor activity of an inhibitor of 26S proteasome bortezomib (Velcade) has been
observed in various malignancies, including colon cancer, prostate cancer, breast cancer …

Autophagy is a dynamic cell survival mechanism by which a double-membrane vesicle, or
autophagosome, sequesters portions of the cytosol for delivery to the lysosome for recycling …