Neuregulin-ERBB signaling in the nervous system and neuropsychiatric diseases

L Mei, KA Nave - Neuron, 2014 - cell.com
Neuregulins (NRGs) comprise a large family of growth factors that stimulate ERBB receptor
tyrosine kinases. NRGs and their receptors, ERBBs, have been identified as susceptibility …

The neuregulin signaling pathway and schizophrenia: from genes to synapses and neural circuits

A Buonanno - Brain research bulletin, 2010 - Elsevier
Numerous genetic linkage and association studies implicate members of the Neuregulin-
ErbB receptor (NRG-ErbB) signaling pathway as schizophrenia “at risk” genes. An emphasis …

Self-domestication in Homo sapiens: Insights from comparative genomics

C Theofanopoulou, S Gastaldon, T O'Rourke… - PloS one, 2017 - journals.plos.org
This study identifies and analyzes statistically significant overlaps between selective sweep
screens in anatomically modern humans and several domesticated species. The results …

Erbb4 deletion from fast-spiking interneurons causes schizophrenia-like phenotypes

I Del Pino, C García-Frigola, N Dehorter… - Neuron, 2013 - cell.com
Genetic variation in neuregulin and its ErbB4 receptor has been linked to schizophrenia,
although little is known about how they contribute to the disease process. Here, we have …

Refinement and discovery of new hotspots of copy-number variation associated with autism spectrum disorder

S Girirajan, MY Dennis, C Baker, M Malig… - The American Journal of …, 2013 - cell.com
Rare copy-number variants (CNVs) have been implicated in autism and intellectual
disability. These variants are large and affect many genes but lack clear specificity toward …

Genome-wide association of endophenotypes for schizophrenia from the Consortium on the Genetics of Schizophrenia (COGS) study

TA Greenwood, LC Lazzeroni, AX Maihofer… - JAMA …, 2019 - jamanetwork.com
Importance The Consortium on the Genetics of Schizophrenia (COGS) uses quantitative
neurophysiological and neurocognitive endophenotypes with demonstrated deficits in …

Infection and inflammation in schizophrenia and bipolar disorder: a genome wide study for interactions with genetic variation

D Avramopoulos, BD Pearce, J McGrath, P Wolyniec… - PloS one, 2015 - journals.plos.org
Inflammation and maternal or fetal infections have been suggested as risk factors for
schizophrenia (SZ) and bipolar disorder (BP). It is likely that such environmental effects are …

Common genetic variation in Neuregulin 3 (NRG3) influences risk for schizophrenia and impacts NRG3 expression in human brain

WT Kao, Y Wang, JE Kleinman… - Proceedings of the …, 2010 - National Acad Sciences
Structural and polymorphic variations in Neuregulin 3 (NRG3), 10q22-23 are associated
with a broad spectrum of neurodevelopmental disorders including developmental delay …

Elucidating the genetic architecture of familial schizophrenia using rare copy number variant and linkage scans

B Xu, A Woodroffe… - Proceedings of the …, 2009 - National Acad Sciences
To elucidate the genetic architecture of familial schizophrenia we combine linkage analysis
with studies of fine-level chromosomal variation in families recruited from the Afrikaner …

Relationship of the Brief UCSD Performance‐based Skills Assessment (UPSA‐B) to multiple indicators of functioning in people with schizophrenia and bipolar …

BT Mausbach, PD Harvey, AE Pulver… - Bipolar …, 2010 - Wiley Online Library
Mausbach BT, Harvey PD, Pulver AE, Depp CA, Wolyniec PS, Thornquist MH, Luke JR,
McGrath JA, Bowie CR, Patterson TL. Relationship of the Brief UCSD Performance‐based …