Neuregulin-ERBB signaling in the nervous system and neuropsychiatric diseases
Neuregulins (NRGs) comprise a large family of growth factors that stimulate ERBB receptor
tyrosine kinases. NRGs and their receptors, ERBBs, have been identified as susceptibility …
tyrosine kinases. NRGs and their receptors, ERBBs, have been identified as susceptibility …
The neuregulin signaling pathway and schizophrenia: from genes to synapses and neural circuits
A Buonanno - Brain research bulletin, 2010 - Elsevier
Numerous genetic linkage and association studies implicate members of the Neuregulin-
ErbB receptor (NRG-ErbB) signaling pathway as schizophrenia “at risk” genes. An emphasis …
ErbB receptor (NRG-ErbB) signaling pathway as schizophrenia “at risk” genes. An emphasis …
Self-domestication in Homo sapiens: Insights from comparative genomics
This study identifies and analyzes statistically significant overlaps between selective sweep
screens in anatomically modern humans and several domesticated species. The results …
screens in anatomically modern humans and several domesticated species. The results …
Erbb4 deletion from fast-spiking interneurons causes schizophrenia-like phenotypes
I Del Pino, C García-Frigola, N Dehorter… - Neuron, 2013 - cell.com
Genetic variation in neuregulin and its ErbB4 receptor has been linked to schizophrenia,
although little is known about how they contribute to the disease process. Here, we have …
although little is known about how they contribute to the disease process. Here, we have …
Refinement and discovery of new hotspots of copy-number variation associated with autism spectrum disorder
S Girirajan, MY Dennis, C Baker, M Malig… - The American Journal of …, 2013 - cell.com
Rare copy-number variants (CNVs) have been implicated in autism and intellectual
disability. These variants are large and affect many genes but lack clear specificity toward …
disability. These variants are large and affect many genes but lack clear specificity toward …
Genome-wide association of endophenotypes for schizophrenia from the Consortium on the Genetics of Schizophrenia (COGS) study
Importance The Consortium on the Genetics of Schizophrenia (COGS) uses quantitative
neurophysiological and neurocognitive endophenotypes with demonstrated deficits in …
neurophysiological and neurocognitive endophenotypes with demonstrated deficits in …
Infection and inflammation in schizophrenia and bipolar disorder: a genome wide study for interactions with genetic variation
D Avramopoulos, BD Pearce, J McGrath, P Wolyniec… - PloS one, 2015 - journals.plos.org
Inflammation and maternal or fetal infections have been suggested as risk factors for
schizophrenia (SZ) and bipolar disorder (BP). It is likely that such environmental effects are …
schizophrenia (SZ) and bipolar disorder (BP). It is likely that such environmental effects are …
Common genetic variation in Neuregulin 3 (NRG3) influences risk for schizophrenia and impacts NRG3 expression in human brain
WT Kao, Y Wang, JE Kleinman… - Proceedings of the …, 2010 - National Acad Sciences
Structural and polymorphic variations in Neuregulin 3 (NRG3), 10q22-23 are associated
with a broad spectrum of neurodevelopmental disorders including developmental delay …
with a broad spectrum of neurodevelopmental disorders including developmental delay …
Elucidating the genetic architecture of familial schizophrenia using rare copy number variant and linkage scans
B Xu, A Woodroffe… - Proceedings of the …, 2009 - National Acad Sciences
To elucidate the genetic architecture of familial schizophrenia we combine linkage analysis
with studies of fine-level chromosomal variation in families recruited from the Afrikaner …
with studies of fine-level chromosomal variation in families recruited from the Afrikaner …
Relationship of the Brief UCSD Performance‐based Skills Assessment (UPSA‐B) to multiple indicators of functioning in people with schizophrenia and bipolar …
BT Mausbach, PD Harvey, AE Pulver… - Bipolar …, 2010 - Wiley Online Library
Mausbach BT, Harvey PD, Pulver AE, Depp CA, Wolyniec PS, Thornquist MH, Luke JR,
McGrath JA, Bowie CR, Patterson TL. Relationship of the Brief UCSD Performance‐based …
McGrath JA, Bowie CR, Patterson TL. Relationship of the Brief UCSD Performance‐based …