Study of drug resistance-associated genetic mutations, and phylo-genetic analysis of HCV in the Province of Sindh, Pakistan

S Faiz, M Irfan, S Farooq, IA Khan, H Iqbal, A Wahab… - Scientific Reports, 2023 - nature.com
Current management of HCV infection is based on Direct-Acting Antiviral Drugs (DAAs).
However, resistance-associated mutations, especially in the NS3 and NS5B regions are …

HIV co-receptor tropism usage: first report from the Iranian patients

F Ghasabi, A Hashempour, N Khodadad… - Future …, 2023 - Taylor & Francis
Aim: The HIV-V3 sequence influences tropism via the interaction of HIV with CCR5 and
CXCR4 coreceptors; however, no consistent sequence accounts for R5 or X4-virus …

HIV capsid and protease, new targets of melittin

B Dehghani, Z Hasanshahi, T Hashempour - International Journal of …, 2020 - Springer
Melittin is a 26 amino acid amphipathic peptide, the main part of a bee venom. It has been
confirmed that melittin can act against a vast verity of infectious agents, such as human …

First report on molecular docking analysis and drug resistance substitutions to approved HCV NS5A and NS5B inhibitors amongst Iranian patients

Z Hasanshahi, A Hashempour, F Ghasabi… - Bmc …, 2021 - Springer
Abstract Background NS5A and NS5B proteins of hepatitis C virus (HCV) are the main
targets of compounds that directly inhibit HCV infections. However, the emergence of …

[HTML][HTML] Comparison of the inhibitory and stimulatory effects of Core and NS3 candidate HCV vaccines on the cellular immune response

K Borhani, T Bamdad, A Hashempour… - American Journal of …, 2023 - ncbi.nlm.nih.gov
Currently, hepatitis C virus (HCV) infects nearly 3% of the global population, the majority of
whom are chronically infected; however, hepatitis C vaccines are still in the developmental …

[HTML][HTML] First report of computational protein–ligand docking to evaluate susceptibility to HIV integrase inhibitors in HIV-infected Iranian patients

F Ghasabi, A Hashempour, N Khodadad… - … and Biophysics Reports, 2022 - Elsevier
Background Iran has recently included integrase (INT) inhibitors (INTIs) in the first‐line
treatment regimen in human immunodeficiency virus (HIV)-infected patients. However, there …

Reverse vaccinology approaches to design a potent multiepitope vaccine against the HIV whole genome: immunoinformatic, bioinformatics, and molecular dynamics …

A Hashempour, N Khodadad, S Akbarinia… - BMC infectious …, 2024 - Springer
Substantial advances have been made in the development of promising HIV vaccines to
eliminate HIV-1 infection. For the first time, one hundred of the most submitted HIV subtypes …

Design of multivalent-epitope vaccine models directed toward the world's population against HIV-Gag polyprotein: Reverse vaccinology and immunoinformatics

A Hashempour, N Khodadad, P Bemani, Y Ghasemi… - Plos one, 2024 - journals.plos.org
Significant progress has been made in HIV-1 research; however, researchers have not yet
achieved the objective of eradicating HIV-1 infection. Accordingly, in this study, eucaryotic …

Interaction Between Vpx and SAMHD1, Vital for SAMHD1 Inhibition

Z Hasanshahi, B Dehghani… - AIDS Research and …, 2024 - liebertpub.com
It was confirmed that the sterile alpha motif and HD domain 1 (SAMHD1) limits human
immunodeficiency virus type 1 (HIV-1) replication. In contrast, viral protein x (Vpx) in HIV-2 …

Impact of IL28 genotypes and modeling the interactions of HCV core protein on treatment of hepatitis C

T Hashempour, B Dehghani, Z Musavi… - Interdisciplinary …, 2020 - Springer
Background Mutations in the core CVR region of hepatitis C virus (HCV) and polymorphisms
of interleukin 28B (IL28B) are associated with progression toward liver disease and in …