AIM/CD5L: a key protein in the control of immune homeostasis and inflammatory disease

L Sanjurjo, G Aran, N Roher… - Journal of Leucocyte …, 2015 - academic.oup.com
CD5L, a soluble protein belonging to the SRCR superfamily, is expressed mostly by
macrophages in lymphoid and inflamed tissues. The expression of this protein is …

Hyaluronic acid as a non-invasive biomarker of liver fibrosis

MG Neuman, LB Cohen, RM Nanau - Clinical biochemistry, 2016 - Elsevier
Chronic liver diseases may cause inflammation and progressive scarring, over time leading
to irreversible hepatic damage (cirrhosis). As a result, the need to assess and closely …

Apoptosis inhibitor of macrophage protein enhances intraluminal debris clearance and ameliorates acute kidney injury in mice

S Arai, K Kitada, T Yamazaki, R Takai, X Zhang… - Nature medicine, 2016 - nature.com
Acute kidney injury (AKI) is associated with prolonged hospitalization and high mortality, and
it predisposes individuals to chronic kidney disease. To date, no effective AKI treatments …

CD5L promotes M2 macrophage polarization through autophagy-mediated upregulation of ID3

L Sanjurjo, G Aran, É Téllez, N Amézaga… - Frontiers in …, 2018 - frontiersin.org
CD5L (CD5 molecule-like) is a secreted glycoprotein that controls key mechanisms in
inflammatory responses, with involvement in processes such as infection, atherosclerosis …

CD5L is upregulated in hepatocellular carcinoma and promotes liver cancer cell proliferation and antiapoptotic responses by binding to HSPA5 (GRP78)

G Aran, L Sanjurjo, C Barcena… - The FASEB …, 2018 - Wiley Online Library
CD5‐like (CD5L) is a soluble scavenger cysteine‐rich protein that modulates inflammatory
responses. We studied the involvement of CD5L in liver cancer. Immunohistochemistry (IHC) …

[HTML][HTML] AIM/CD5L ameliorates autoimmune arthritis by promoting removal of inflammatory DAMPs at the lesions

K Yasuda, S Shimodan, N Maehara, A Hirota… - Journal of …, 2024 - Elsevier
The hallmark of autoimmune arthritis is the preceding autoantibody production and the
following synovial inflammation with hyperplasia and tissue destruction of the joints. The …

CD5L is a pleiotropic player in liver fibrosis controlling damage, fibrosis and immune cell content

C Bárcena, G Aran, L Perea, L Sanjurjo, É Téllez… - …, 2019 - thelancet.com
Background Chronic hepatic inflammation leads to liver fibrosis, which may progress to
cirrhosis, a condition with high morbidity. Our aim was to assess the as yet unknown role of …

CD5L contributes to the pathogenesis of methicillin-resistant Staphylococcus aureus-induced pneumonia

X Gao, X Yan, Q Zhang, Y Yin, J Cao - International Immunopharmacology, 2019 - Elsevier
Staphylococcus aureus is a major causative microorganism in community-and healthcare-
acquired pneumonia. CD5L is an important protein in the control of immune homeostasis. In …

Assessment of apoptosis inhibitor of macrophage/CD5L as a biomarker to predict mortality in the critically ill with sepsis

X Gao, Y Liu, F Xu, S Lin, Z Song, J Duan, Y Yin, J Cao - Chest, 2019 - Elsevier
Background To determine the utility of apoptosis inhibitor of macrophage (AIM)/CD5L as a
potentially novel biomarker of morbidity and mortality in patients with sepsis who are …

Serum cytokines, adipokines and ferritin for non-invasive assessment of liver fibrosis in chronic liver disease: a systematic review

SM Haghgoo, H Sharafi, SM Alavian - Clinical Chemistry and …, 2019 - degruyter.com
Chronic liver disease (CLD) is a major health problem worldwide. Non-alcoholic fatty liver
disease (NAFLD), chronic hepatitis C (CHC), chronic hepatitis B (CHB), and alcoholic liver …