Challenges to DNA replication in hypoxic conditions
N Ng, K Purshouse, IP Foskolou, MM Olcina… - The FEBS …, 2018 - Wiley Online Library
The term hypoxia refers to any condition where insufficient oxygen is available and therefore
encompasses a range of actual oxygen concentrations. The regions of tumours adjacent to …
encompasses a range of actual oxygen concentrations. The regions of tumours adjacent to …
[HTML][HTML] Everything in moderation: lessons learned by exploiting moderate replication stress in cancer
The poor selectivity of standard cytotoxic chemotherapy regimens causes severe side-
effects in patients and reduces the quality of life during treatment. Targeting cancer-specific …
effects in patients and reduces the quality of life during treatment. Targeting cancer-specific …
[HTML][HTML] RRM2B is frequently amplified across multiple tumor types: implications for DNA repair, cellular survival, and cancer therapy
W Iqbal, EV Demidova, S Serrao… - Frontiers in …, 2021 - frontiersin.org
RRM2B plays a crucial role in DNA replication, repair and oxidative stress. While germline
RRM2B mutations have been implicated in mitochondrial disorders, its relevance to cancer …
RRM2B mutations have been implicated in mitochondrial disorders, its relevance to cancer …
[HTML][HTML] Targeting matrix metallopeptidase 2 by hydroxyurea selectively kills acute myeloid mixed-lineage leukemia
Oncogene-induced tumorigenesis results in the variation of epigenetic modifications, and in
addition to promoting cell immortalization, cancer cells undergo more intense cellular stress …
addition to promoting cell immortalization, cancer cells undergo more intense cellular stress …
RRM2B is frequently amplified across multiple tumor types: non-oncogenic addiction and therapeutic opportunities
W Iqbal, EV Demidova, S Serrao, T ValizadehAslani… - bioRxiv, 2020 - biorxiv.org
RRM2B plays a crucial role in DNA replication, repair and oxidative stress. While germline
RRM2B mutations have been implicated in mitochondrial disorders, its relevance to cancer …
RRM2B mutations have been implicated in mitochondrial disorders, its relevance to cancer …