A multimodal omics framework to empower target discovery for cardiovascular regeneration
Ischaemic heart disease is a global healthcare challenge with high morbidity and mortality.
Early revascularisation in acute myocardial infarction has improved survival; however …
Early revascularisation in acute myocardial infarction has improved survival; however …
Identification and characterization of Hand2 upstream genomic enhancers active in developing stomach and limbs
CA Ferguson, BA Firulli, M Zoia… - Developmental …, 2024 - Wiley Online Library
Background The bHLH transcription factor HAND2 plays important roles in the development
of the embryonic heart, face, limbs, and sympathetic and enteric nervous systems. To define …
of the embryonic heart, face, limbs, and sympathetic and enteric nervous systems. To define …
[HTML][HTML] A disrupted compartment boundary underlies abnormal cardiac patterning and congenital heart defects
IS Kathiriya, MH Dominguez, KS Rao, JM Muncie-Vasic… - bioRxiv, 2024 - ncbi.nlm.nih.gov
Failure of septation of the interventricular septum (IVS) is the most common congenital heart
defect (CHD), but mechanisms for patterning the IVS are largely unknown. We show that a …
defect (CHD), but mechanisms for patterning the IVS are largely unknown. We show that a …
[HTML][HTML] Plxnd1-mediated mechanosensing of blood flow controls the caliber of the Dorsal Aorta via the transcription factor Klf2
J He, A Blazeski, U Nilanthi, J Menéndez, SC Pirani… - bioRxiv, 2024 - ncbi.nlm.nih.gov
The cardiovascular system generates and responds to mechanical forces. The heartbeat
pumps blood through a network of vascular tubes, which adjust their caliber in response to …
pumps blood through a network of vascular tubes, which adjust their caliber in response to …
A TBX5-dependent compartment boundary patterns the cardiac interventricular septum.
IS Kathiriya, MH Dominguez, KS Rao… - Biorxiv: the Preprint …, 2024 - europepmc.org
Failure of septation of the interventricular septum (IVS) is the most common congenital heart
defect (CHD), but mechanisms for patterning the IVS are largely unknown. We show that a …
defect (CHD), but mechanisms for patterning the IVS are largely unknown. We show that a …
Single-nuclei multiomics analysis of cardiogenic transcription factors in a new murine model of cardiac development
Transcription factors such as Tbx5, Gata4, Mef2c and Pitx2 are required during cardiac
development, and in adult cardiac homeostasis. We demonstrate that the gene dosage and …
development, and in adult cardiac homeostasis. We demonstrate that the gene dosage and …
[PDF][PDF] Dynamic model inference of gene regulatory network based on hybrid parallel genetic algorithm and threshold qualification method
X Ding, H Ding, F Zhou - International Journal Bioautomation, 2024 - biomed.bas.bg
Gene regulation is the process by which various substances in cells regulate the behaviour
of gene expression, thereby controlling almost all cellular activities. Therefore, studying …
of gene expression, thereby controlling almost all cellular activities. Therefore, studying …
[图书][B] Identification of Transcriptional Enhancers in Development and Disease
BJ Mannion - 2023 - search.proquest.com
Enhancers are non-coding DNA elements found throughout the genome that, in concert with
transcription factors, coactivators, and general transcriptional machinery, activate cell-type …
transcription factors, coactivators, and general transcriptional machinery, activate cell-type …