The past several decades have witnessed great progress in the understanding of the high-
order structure of biomacromolecules. Currently, it is well-recognized that folding of proteins …

Foldamers are sequence-specific oligomers akin to peptides, proteins and oligonucleotides
that fold into well-defined three-dimensional structures. They offer the chemical biologist a …

Aromatic oligoamide foldamers possess a high potential for mimicking the secondary
structures of biopolymers. These oligomers are efficiently designed, easy to synthesize, and …

The transport of molecules and ions across nanometer-scaled pores, created by natural or
artificial molecules, is a phenomenon of both fundamental and practical significance …

Unlike many other biologically relevant ions (Na+, K+, Ca2+, Cl−, etc) and protons, whose
cellular concentrations are closely regulated by highly selective channel proteins, Li+ ion is …

The convergent positioning of functional groups in biomacromolecules leads to good
binding, catalytic and transport capabilities. Synthetic frameworks capable of convergently …

This Account reviews the progress made by us on creating porous molecular crescents,
helices, and macrocycles based on aromatic oligoamides. Inspired by natural pore-or cavity …

This paper describes the synthesis and characterization of the first series of hydrogen
bonding-driven hydrazide foldamers and their recognition for alkyl saccharides in …

The development of structurally defined peptide units is an important prerequisite for protein
design. The search for oligopeptides having stable conformations in solution, socalled …

Oligomers that adopt predictable conformations (“foldamers”) are subjects of increasing
interest from the perspectives of both fundamental research and applications.[1] The study of …