Highlights•Multimodal measurements are critical to systems biology approaches at the
single-cell level.•MS provides diverse molecular measurements in multimodal …

One of the challenges facing biology is to understand metabolic events at a single cellular
level. While approaches to examine dynamics of protein distribution or report on …

Identification of features with high levels of confidence in liquid chromatography–mass
spectrometry (LC–MS) lipidomics research is an essential part of biomarker discovery, but …

Single-cell analysis by mass spectrometry (MS) is emerging as a powerful tool that not only
contributes to cellular heterogeneity but also offers an unprecedented opportunity to predict …

We report the first demonstration of a microfluidics-based approach to measure lipids in
single living cells using widely available liquid chromatography mass spectrometry (LC-MS) …

Tumor metastasis and cancer recurrence are often a result of cell heterogeneity, where
specific subpopulations of tumor cells may be resistant to radio-or chemotherapy. To …

We report the development and validation of an untargeted single-cell lipidomics method
based on microflow chromatography coupled to a data-dependent mass spectrometry …

It is well established that a population of single human cells will often respond to the same
drug treatment in a heterogeneous manner. In the context of chemotherapeutics, these …

We report the development and validation of an untargeted single-cell lipidomics method
based on microflow chromatography coupled to a data-dependent mass spectrometry …

Metabolomics is the omics discipline concerned with the study of small molecules which are
involved in cellular metabolism and include substrates, metabolic intermediates, and …