In mammals, erythropoietin (EPO), produced in the kidney, is essential for bone marrow
erythropoiesis, and hypoxia induction of EPO production provides for the important …

Sufficient oxygen is required to maintain normal cellular and physiological function, such as
a creature's development, breeding, and homeostasis. Lately, some researchers have …

Stroma is a poorly defined non-parenchymal component of virtually every organ with key
roles in organ development, homeostasis, and repair. Studies of the bone marrow stroma …

The fast osteogenesis of the large alveolar fossa and the maintenance of the height of the
alveolar ridge after tooth extraction have always been a clinical challenge. Therefore, this …

Preservation of bone mass is crucial for healthy ageing and largely depends on adequate
responses of matrix-embedded osteocytes. These cells control bone formation and …

Hypoxia-inducible factor (HIF) plays a crucial role in the response to hypoxia at the cellular,
tissue, and organism level. New agents under development to pharmacologically …

In search of the sequence of pathogenic events leading to glucocorticoid-induced
osteonecrosis, we determined the molecular, biomechanical, cellular, and vascular changes …

Abstract Fibroblast growth factor 23 (FGF23) is a major endocrine regulator of phosphate
and 1, 25 (OH) 2 vitamin D 3 metabolism and is mainly produced by osteocytes. Its …

To maintain normal cellular and physiological function, sufficient oxygen is required.
Recently, evidence has suggested that hypoxia, either pathological or environmental, may …

Plasma levels of FGF23 are increased in patients with chronic kidney disease. Beside its
role in phosphate homeostasis, iron deficiency and anemia are associated with increased …