The phenotypic and biochemical similarities between caspase-mediated apoptosis and
cellular differentiation are striking. They include such diverse phenomenon as mitochondrial …

Neurotrophins have been intensively studied and have multiple roles in the brain.
Neurotrophins are first synthetized as proneurotrophins and then cleaved intracellularly and …

Mitophagy eliminates dysfunctional mitochondria, and defects in this cellular housekeeping
mechanism are implicated in various age-related diseases. Here, we found that mitophagy …

Amyloid β-protein (Aβ) toxicity is hypothesized to play a seminal role in Alzheimer's disease
(AD) pathogenesis. However, it remains unclear how Aβ causes synaptic dysfunction and …

Muscle atrophy derived from excessive proteolysis is a hallmark of numerous disease
conditions. Accordingly, the negative consequences of skeletal muscle protein breakdown …

Impaired synaptic plasticity and dendritic loss in excitatory glutamatergic synapses are early
events in Alzheimer disease (AD). These synaptic abnormalities are triggered by …

Adult-born neurons are continually produced in the dentate gyrus but it is unclear whether
synaptic integration of new neurons affects the pre-existing circuit. Here we investigated how …

Highlights•Axotomy, axon apoptosis, and axon pruning engage distinct pathways of
degeneration.•NMNATs and SARM1 are key mediators of axotomy-induced axon …

WDHHAPQLR (RAP) is an antioxidative peptide derived from rapeseed protein. Although
the health benefits from RAP, due to its antioxidant activities, have been determined by …

Cell death is an inherent process that is required for the proper wiring of the nervous system.
Studies over the last four decades have shown that, in a parallel developmental pathway …