[HTML][HTML] Repurposing anticancer drugs for the management of COVID-19

K El Bairi, D Trapani, A Petrillo, C Le Page… - European Journal of …, 2020 - Elsevier
Since its outbreak in the last December, coronavirus disease 2019 (COVID-19) caused by
SARS-CoV-2 has rapidly spread worldwide at a pandemic proportion and thus is regarded …

Gynecological cancer prognosis using machine learning techniques: A systematic review of the last three decades (1990–2022)

J Sheehy, H Rutledge, UR Acharya, HW Loh… - Artificial Intelligence in …, 2023 - Elsevier
Abstract Objective Many Computer Aided Prognostic (CAP) systems based on machine
learning techniques have been proposed in the field of oncology. The objective of this …

Morusin induces paraptosis-like cell death through mitochondrial calcium overload and dysfunction in epithelial ovarian cancer

J Xue, R Li, X Zhao, C Ma, X Lv, L Liu, P Liu - Chemico-biological …, 2018 - Elsevier
Epithelial ovarian cancer (EOC) is the leading cause of death among all gynecological
cancers. Morusin, a prenylated flavonoid extracted from the root bark of Morus australis, has …

Decoding colorectal cancer epigenomics

K El Bairi, K Tariq, I Himri, A Jaafari, W Smaili… - Cancer genetics, 2018 - Elsevier
Highlights•Epigenetic alterations are an emerging factor in colorectal carcinogenesis.•The
discovery of epigenetic pathways constitutes a major advance in cancer biomarker …

EIF5A2 enhances stemness of epithelial ovarian cancer cells via a E2F1/KLF4 axis

K Wang, Y Wang, Y Wang, S Liu, C Wang… - Stem Cell Research & …, 2021 - Springer
Background Ovarian cancer stem cells (OCSC), endowed with tumor-initiating and self-
renewal capacity, would account not only for the tumor growth, the peritoneal metastasis …

Potential drug development and therapeutic approaches for clinical intervention in COVID-19

J Dowarah, BN Marak, UCS Yadav, VP Singh - Bioorganic Chemistry, 2021 - Elsevier
While the vaccination is now available to many countries and will slowly dissipate to others,
effective therapeutics for COVID-19 is still illusive. The SARS-CoV-2 pandemic has posed …

S100A10 and cancer hallmarks: structure, functions, and its emerging role in ovarian cancer

TM Noye, NA Lokman, MK Oehler… - International journal of …, 2018 - mdpi.com
S100A10, which is also known as p11, is located in the plasma membrane and forms a
heterotetramer with annexin A2. The heterotetramer, comprising of two subunits of annexin …

[HTML][HTML] The arrival of predictive biomarkers for monitoring therapy response to natural compounds in cancer drug discovery

K El Bairi, AG Atanasov, M Amrani, S Afqir - Biomedicine & …, 2019 - Elsevier
Intrinsic or acquired drug resistance, adverse drug reactions and tumor heterogeneity
between and within cancer patients limit the efficacy of clinical management of advanced …

Revisiting antibody-drug conjugates and their predictive biomarkers in platinum-resistant ovarian cancer

K El Bairi, O Al Jarroudi, S Afqir - Seminars in Cancer Biology, 2021 - Elsevier
Until to date, platinum derived drugs are still the backbone of treating ovarian cancer (OC).
Most patients treated with platinum-based chemotherapy develop resistance during the …

CCNG1 (Cyclin G1) regulation by mutant‐P53 via induction of Notch3 expression promotes high‐grade serous ovarian cancer (HGSOC) tumorigenesis and …

Y Xu, Q Zhang, C Miao, S Dongol, Y Li, C Jin… - Cancer …, 2019 - Wiley Online Library
TP53 mutation is considerably common in advanced high‐grade serous ovarian cancer
(HGSOC) and significantly associated with a poor prognosis. In this study, we investigated …