Causes, consequences and public health implications of low B-vitamin status in ageing

K Porter, L Hoey, CF Hughes, M Ward, H McNulty - Nutrients, 2016 - mdpi.com
The potential protective roles of folate and the metabolically related B-vitamins (vitamins
B12, B6 and riboflavin) in diseases of ageing are of increasing research interest. The most …

Neuroprotective effects of choline and other methyl donors

RA Bekdash - Nutrients, 2019 - mdpi.com
Recent evidence suggests that physical and mental health are influenced by an intricate
interaction between genes and environment. Environmental factors have been shown to …

[HTML][HTML] Early childhood cognitive development is affected by interactions among illness, diet, enteropathogens and the home environment: findings from the MAL-ED …

Mal-Ed Network Investigators - BMJ Global Health, 2018 - gh.bmj.com
Background Millions of children in low-income and middle-income countries (LMICs) are at
risk of not reaching their full cognitive potential. Malnutrition and enteric infections in early …

[HTML][HTML] Gene-specific DNA methylation in newborns in response to folic acid supplementation during the second and third trimesters of pregnancy: epigenetic …

A Caffrey, RE Irwin, H McNulty, JJ Strain… - The American journal of …, 2018 - Elsevier
Background Emerging evidence suggests that maternal folate status can impact cognitive
development in childhood. Folate-dependent DNA methylation may provide a biological …

[HTML][HTML] The importance of maternal folate status for brain development and function of offspring

EFG Naninck, PC Stijger, EM Brouwer-Brolsma - Advances in Nutrition, 2019 - Elsevier
The importance of an adequate periconceptional maternal folate status to prevent fetal
neural tube defects has been well demonstrated and resulted in the recommendation for …

Folates: Chemistry, analysis, occurrence, biofortification and bioavailability

RK Saini, SH Nile, YS Keum - Food Research International, 2016 - Elsevier
Folates (Vitamin B 9) include both naturally occurring folates and synthetic folic acid used in
fortified foods and dietary supplements. Folate deficiency causes severe abnormalities in …

HDAC1 links early life stress to schizophrenia-like phenotypes

S Bahari-Javan, H Varbanov… - Proceedings of the …, 2017 - National Acad Sciences
Schizophrenia is a devastating disease that arises on the background of genetic
predisposition and environmental risk factors, such as early life stress (ELS). In this study …

Addressing optimal folate and related B-vitamin status through the lifecycle: health impacts and challenges

H McNulty, M Ward, L Hoey, CF Hughes… - Proceedings of the …, 2019 - cambridge.org
The functional effects of folate within C1 metabolism involve interrelationships with vitamin
B12, vitamin B6 and riboflavin, and related gene–nutrient interactions. These B vitamins …

Effect of continued folic acid supplementation beyond the first trimester of pregnancy on cognitive performance in the child: a follow-up study from a randomized …

H McNulty, M Rollins, T Cassidy, A Caffrey, B Marshall… - BMC medicine, 2019 - Springer
Background Periconceptional folic acid prevents neural tube defects (NTDs), but it is
uncertain whether there are benefits for offspring neurodevelopment arising from continued …

Eating disorders during gestation: implications for mother's health, fetal outcomes, and epigenetic changes

G Sebastiani, V Andreu-Fernández… - Frontiers in …, 2020 - frontiersin.org
Introduction: Eating disorders (EDs) have increased globally in women of childbearing age,
related to the concern for body shape promoted in industrialized countries. Pregnancy may …