In 2000, The International Nomenclature Committee for Pediatric and Congenital Heart
Disease was established. This committee eventually evolved into the International Society …

Molecular and genetic studies around the turn of this century have revolutionized the field of
cardiac development. We now know that the primary heart tube, as seen in the early embryo …

Rationale: Extraembryonic tissues, including the yolk sac and placenta, and the heart within
the embryo, work to provide crucial nutrients to the embryo. The association of congenital …

Insight into the mechanisms underlying congenital heart defects and the use of stem cells for
cardiac repair are major research goals in cardiovascular biology. In the early embryo …

Congenital heart disease (CHD) affects nearly 1% of the population. It is a complex disease,
which may be caused by multiple genetic and environmental factors. Studies in human …

Fibroblast growth factor 8 (Fgf8) is a secreted signaling protein expressed in numerous
temporospatial domains that are potentially relevant to cardiovascular development …

Extensive studies have shown how bilateral symmetry of the vertebrate embryo is broken
during early development, resulting in a molecular left-right bias in the mesoderm. However …

Abstract Wessels MW, Willems PJ. Genetic factors in non-syndromic congenital heart
malformations. The genetic defect in most patients with non-syndromic congenital heart …

Cellular and molecular left–right differences that are present in the mesodermal heart fields
suggest that the heart is lateralized from its inception. Left–right asymmetry persists as the …

The molecular basis for acquisition of meiotic and developmental competence, the two main
outcomes of oocyte development and essential for producing an egg capable of being …