Oxylipins are bioactive metabolites derived from the oxygenation of ω3 and ω6
polyunsaturated fatty acids, triggered essentially by cyclooxygenase and lipoxygenase …

Cyclooxygenases (COX) are enzymes catalyzing arachidonic acid into prostanoids. COX
exists in three isoforms: COX-1, 2, and 3. COX-1 and COX-2 have been widely studied in …

Background It is well known that the microbiota of high-fat (HF) diet-induced obese mice
differs from that of lean mice, but to what extent, this difference reflects the obese state or the …

The vertebrate gut microbiota have been implicated in the metabolism of xenobiotic
compounds, motivating studies of microbe-driven metabolism of clinically important drugs …

Objective Brite adipocytes are inducible energy-dissipating cells expressing UCP1 which
appear within white adipose tissue of healthy adult individuals. Recruitment of these cells …

The recent characterization of functional brown adipose tissue in adult humans has opened
new perspectives for regulation of energy expenditure with respect to obesity and diabetes …

abstract The notion that the obesogenic potential of high fat diets in rodents is attenuated
when the protein: carbohydrate ratio is increased is largely based on studies using casein or …

The aim of our study is to elucidate the mechanisms of oleanolic acid (OA) on insulin
resistance (IR) in HepG2 cells. HepG2 cells were induced with FFA as the insulin resistance …

In this study, we aimed to evaluate the impact of consuming refined mackerel oil (MO) from
rest raw material on hepatic fat accumulation, glucose tolerance, and metabolomic changes …

Emerging evidence indicates that the fatty acid composition of obesogenic diets influences
physiologic outcomes. There are scant data regarding how the content of non-essential fatty …