Pancreatic β-cells are finely tuned to secrete insulin so that plasma glucose levels are
maintained within a narrow physiological range (3.5-5.5 mmol/L). Hyperinsulinaemic …

Abstract Potassium channels (K+-channels) selectively control the passive flow of potassium
ions across biological membranes and thereby also regulate membrane excitability. Genetic …

Glucose, like oxygen, is of fundamental importance for any living being and it is the major
energy source for the fetus and the neonate during gestation. The placenta ensures a steady …

Dunne, Mark J., Karen E. Cosgrove, Ruth M. Shepherd, Albert Aynsley-Green, and Keith J.
Lindley. Hyperinsulinism in Infancy: From Basic Science to Clinical Disease. Physiol Rev 84 …

Insulin secretion from pancreatic islet beta cells is acutely regulated by a complex interplay
of metabolic and electrogenic events. The electrogenic mechanism regulating insulin …

Hyperinsulinemic hypoglycemia (HH) is characterized by unregulated insulin release,
leading to persistently low blood glucose concentrations with lack of alternative fuels, which …

Hyperinsulinaemic hypoglycaemia (HH) occurs as a consequence of unregulated insulin
secretion from pancreatic β cells. In the newborn period it is the most common cause of …

Post‐bariatric hypoglycaemia (PBH) is a metabolic complication of bariatric surgery (BS),
consisting of low post‐prandial glucose levels in patients having undergone bariatric …

While hypoglycemia occurs commonly among neonates, treatment can be challenging if
hypoglycemia persists beyond the first few days of life. This review discusses the available …

Hyperinsulinaemic hypoglycaemia is a cause of persistent hypoglycaemia in the neonatal
and infancy periods. Prompt recognition and management of patients with …