The Hippo pathway: biology and pathophysiology
The Hippo pathway was initially discovered in Drosophila melanogaster as a key regulator
of tissue growth. It is an evolutionarily conserved signaling cascade regulating numerous …
of tissue growth. It is an evolutionarily conserved signaling cascade regulating numerous …
Hippo–YAP/TAZ signalling in organ regeneration and regenerative medicine
The Hippo pathway and its downstream effectors, the transcriptional co-activators Yes-
associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ) …
associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ) …
The Drosophila embryo at single-cell transcriptome resolution
N Karaiskos, P Wahle, J Alles, A Boltengagen, S Ayoub… - Science, 2017 - science.org
By the onset of morphogenesis, Drosophila embryos consist of about 6000 cells that express
distinct gene combinations. Here, we used single-cell sequencing of precisely staged …
distinct gene combinations. Here, we used single-cell sequencing of precisely staged …
Hippo signaling instructs ectopic but not normal organ growth
The Hippo signaling pathway is widely considered a master regulator of organ growth
because of the prominent overgrowth phenotypes caused by experimental manipulation of …
because of the prominent overgrowth phenotypes caused by experimental manipulation of …
Mechanisms of Hippo pathway regulation
The Hippo pathway was initially identified in Drosophila melanogaster screens for tissue
growth two decades ago and has been a subject extensively studied in both Drosophila and …
growth two decades ago and has been a subject extensively studied in both Drosophila and …
Regulation of cardiomyocyte fate plasticity: a key strategy for cardiac regeneration
R Gong, Z Jiang, N Zagidullin, T Liu… - Signal Transduction and …, 2021 - nature.com
With the high morbidity and mortality rates, cardiovascular diseases have become one of the
most concerning diseases worldwide. The heart of adult mammals can hardly regenerate …
most concerning diseases worldwide. The heart of adult mammals can hardly regenerate …
The roles of YAP/TAZ and the hippo pathway in healthy and diseased skin
E Rognoni, G Walko - Cells, 2019 - mdpi.com
Skin is the largest organ of the human body. Its architecture and physiological functions
depend on diverse populations of epidermal cells and dermal fibroblasts. Reciprocal …
depend on diverse populations of epidermal cells and dermal fibroblasts. Reciprocal …
Repeated inversions within a pannier intron drive diversification of intraspecific colour patterns of ladybird beetles
T Ando, T Matsuda, K Goto, K Hara, A Ito… - Nature …, 2018 - nature.com
How genetic information is modified to generate phenotypic variation within a species is one
of the central questions in evolutionary biology. Here we focus on the striking intraspecific …
of the central questions in evolutionary biology. Here we focus on the striking intraspecific …
The Hippo pathway is controlled by Angiotensin II signaling and its reactivation induces apoptosis in podocytes
DO Wennmann, B Vollenbröker, AK Eckart… - Cell death & …, 2014 - nature.com
The Hippo pathway fulfills a crucial function in controlling the balance between proliferation,
differentiation and apoptosis in cells. Recent studies showed that G protein-coupled …
differentiation and apoptosis in cells. Recent studies showed that G protein-coupled …
Genome editing in the unicellular holozoan Capsaspora owczarzaki suggests a premetazoan role for the Hippo pathway in multicellular morphogenesis
Animal development is mediated by a surprisingly small set of canonical signaling pathways
such as Wnt, Hedgehog, TGF-beta, Notch, and Hippo pathways. Although once thought to …
such as Wnt, Hedgehog, TGF-beta, Notch, and Hippo pathways. Although once thought to …