Recent advances in exosome-mediated nucleic acid delivery for cancer therapy

Y Zhang, Q Liu, X Zhang, H Huang, S Tang… - Journal of …, 2022 - Springer
Cancer is a leading public health problem worldwide. Its treatment remains a daunting
challenge, although significant progress has been made in existing treatments in recent …

[HTML][HTML] Engineering exosomes for targeted drug delivery

Y Liang, L Duan, J Lu, J Xia - Theranostics, 2021 - ncbi.nlm.nih.gov
Exosomes are cell-derived nanovesicles that are involved in the intercellular transportation
of materials. Therapeutics, such as small molecules or nucleic acid drugs, can be …

Therapeutic roles of mesenchymal stem cell-derived extracellular vesicles in cancer

Z Weng, B Zhang, C Wu, F Yu, B Han, B Li… - Journal of hematology & …, 2021 - Springer
Extracellular vesicles (EVs) are cell-derived membrane structures enclosing proteins, lipids,
RNAs, metabolites, growth factors, and cytokines. EVs have emerged as essential …

Exosome engineering in cell therapy and drug delivery

S Sadeghi, FR Tehrani, S Tahmasebi, A Shafiee… - …, 2023 - Springer
Cell-derived exosomes have opened new horizons in modern therapy for advanced drug
delivery and therapeutic applications, due to their key features such as low immunogenicity …

[HTML][HTML] Chondrocyte-specific genomic editing enabled by hybrid exosomes for osteoarthritis treatment

Y Liang, X Xu, L Xu, Z Iqbal, K Ouyang, H Zhang… - Theranostics, 2022 - ncbi.nlm.nih.gov
Rationale: A cell-specific delivery vehicle is required to achieve gene editing of the disease-
associated cells, so the hereditable genome editing reactions are confined within these cells …

A review of the regulatory mechanisms of extracellular vesicles-mediated intercellular communication

YJ Liu, C Wang - Cell Communication and Signaling, 2023 - Springer
Extracellular vesicles (EVs) are small, membrane-bound structures that are released from
cells into the surrounding environment. These structures can be categorized as exosomes …

Recent progress in targeted delivery vectors based on biomimetic nanoparticles

L Chen, W Hong, W Ren, T Xu, Z Qian… - Signal transduction and …, 2021 - nature.com
Over the past decades, great interest has been given to biomimetic nanoparticles (BNPs)
since the rise of targeted drug delivery systems and biomimetic nanotechnology. Biological …

Adaptive design of mRNA-loaded extracellular vesicles for targeted immunotherapy of cancer

S Dong, X Liu, Y Bi, Y Wang, A Antony, DY Lee… - Nature …, 2023 - nature.com
The recent success of mRNA therapeutics against pathogenic infections has increased
interest in their use for other human diseases including cancer. However, the precise …

Advances in exosome-based drug delivery and tumor targeting: from tissue distribution to intracellular fate

J Shao, J Zaro, Y Shen - International journal of nanomedicine, 2020 - Taylor & Francis
Exosomes or small extracellular vesicles are considered a new generation of bioinspired-
nanoscale drug delivery system (DDS). Endogenous exosomes function as signalosomes …

Mesenchymal stem cells-derived exosomes for drug delivery

Y Sun, G Liu, K Zhang, Q Cao, T Liu, J Li - Stem cell research & therapy, 2021 - Springer
Exosomes are extracellular vesicles secreted by various cells, mainly composed of lipid
bilayers without organelles. In recent years, an increasing number of researchers have …