Primed for addiction: A critical review of the role of microglia in the neurodevelopmental consequences of adolescent alcohol drinking

JK Melbourne, CM Chandler… - Alcoholism: Clinical …, 2021 - Wiley Online Library
Alcohol is one of the most widely used recreational substances worldwide, with drinking
frequently initiated during adolescence. The developmental state of the adolescent brain …

The role of sex in the persistent effects of adolescent alcohol exposure on behavior and neurobiology in rodents

DL Robinson, LR Amodeo, LJ Chandler… - International review of …, 2021 - Elsevier
Alcohol drinking is often initiated during adolescence, and this frequently escalates to binge
drinking. As adolescence is also a period of dynamic neurodevelopment, preclinical …

Adolescent alcohol exposure produces protracted cognitive-behavioral impairments in adult male and female rats

V Macht, N Elchert, F Crews - Brain sciences, 2020 - mdpi.com
Binge drinking is common in adolescence. Rodent studies modeling adolescent binge
drinking find persistent effects on the brain's physiology, including increased expression of …

Impact of adolescent intermittent ethanol exposure on interneurons and their surrounding perineuronal nets in adulthood

CA Dannenhoffer, A Gómez‐A… - Alcoholism: Clinical …, 2022 - Wiley Online Library
Background Binge alcohol exposure during adolescence results in long‐lasting alterations
in the brain and behavior. For example, adolescent intermittent ethanol (AIE) exposure in …

[HTML][HTML] Acute alcohol induces greater dose-dependent increase in the lateral cortical network functional connectivity in adult than adolescent rats

SH Lee, TA Shnitko, LM Hsu, MA Broadwater… - Addiction …, 2023 - Elsevier
Alcohol misuse and, particularly adolescent drinking, is a major public health concern. While
evidence suggests that adolescent alcohol use affects frontal brain regions that are …

Therapeutic role of mesenchymal stem cell‐derived extracellular vesicles in neuroinflammation and cognitive dysfunctions induced by binge‐like ethanol treatment in …

S Mellado, CM Cuesta, S Montagud… - CNS Neuroscience …, 2023 - Wiley Online Library
Abstract Background Extracellular vesicles (EVs) are heterogeneous membrane vesicles
secreted by cells in extracellular spaces that play an important role in intercellular …

Modulation of the p75NTR during adolescent alcohol exposure prevents cholinergic neuronal atrophy and associated acetylcholine activity and behavioral …

BT Kipp, LM Savage - International Journal of Molecular Sciences, 2024 - mdpi.com
Binge alcohol consumption during adolescence can produce lasting deficits in learning and
memory while also increasing the susceptibility to substance use disorders. The adolescent …

Behavioral flexibility in alcohol‐drinking monkeys: The morning after

TA Shnitko, SW Gonzales, N Newman… - Alcoholism: Clinical …, 2020 - Wiley Online Library
Background Heavy alcohol drinking has aspects of inflexible behavior. This study addressed
the consequences of chronic alcohol drinking on cognitive and sensory‐motor domains of …

Acute depletion of dopamine precursors in the human brain: effects on functional connectivity and alcohol attentional bias

A Elton, ML Faulkner, DL Robinson… - …, 2021 - nature.com
Individuals who abuse alcohol often show exaggerated attentional bias (AB) towards
alcohol-related cues, which is thought to reflect reward conditioning processes. Rodent …

Adolescent alcohol exposure persistently alters orbitofrontal cortical encoding of Pavlovian conditional stimulus components in female rats

JA Pochapski, A Gómez-A, SJ Stringfield, H Jaggers… - Scientific Reports, 2024 - nature.com
Exposure to alcohol during adolescence impacts cortical and limbic brain regions
undergoing maturation. In rodent models, long-term effects on behavior and …