Primed for addiction: A critical review of the role of microglia in the neurodevelopmental consequences of adolescent alcohol drinking
JK Melbourne, CM Chandler… - Alcoholism: Clinical …, 2021 - Wiley Online Library
Alcohol is one of the most widely used recreational substances worldwide, with drinking
frequently initiated during adolescence. The developmental state of the adolescent brain …
frequently initiated during adolescence. The developmental state of the adolescent brain …
The role of sex in the persistent effects of adolescent alcohol exposure on behavior and neurobiology in rodents
Alcohol drinking is often initiated during adolescence, and this frequently escalates to binge
drinking. As adolescence is also a period of dynamic neurodevelopment, preclinical …
drinking. As adolescence is also a period of dynamic neurodevelopment, preclinical …
Adolescent alcohol exposure produces protracted cognitive-behavioral impairments in adult male and female rats
Binge drinking is common in adolescence. Rodent studies modeling adolescent binge
drinking find persistent effects on the brain's physiology, including increased expression of …
drinking find persistent effects on the brain's physiology, including increased expression of …
Impact of adolescent intermittent ethanol exposure on interneurons and their surrounding perineuronal nets in adulthood
CA Dannenhoffer, A Gómez‐A… - Alcoholism: Clinical …, 2022 - Wiley Online Library
Background Binge alcohol exposure during adolescence results in long‐lasting alterations
in the brain and behavior. For example, adolescent intermittent ethanol (AIE) exposure in …
in the brain and behavior. For example, adolescent intermittent ethanol (AIE) exposure in …
[HTML][HTML] Acute alcohol induces greater dose-dependent increase in the lateral cortical network functional connectivity in adult than adolescent rats
Alcohol misuse and, particularly adolescent drinking, is a major public health concern. While
evidence suggests that adolescent alcohol use affects frontal brain regions that are …
evidence suggests that adolescent alcohol use affects frontal brain regions that are …
Therapeutic role of mesenchymal stem cell‐derived extracellular vesicles in neuroinflammation and cognitive dysfunctions induced by binge‐like ethanol treatment in …
S Mellado, CM Cuesta, S Montagud… - CNS Neuroscience …, 2023 - Wiley Online Library
Abstract Background Extracellular vesicles (EVs) are heterogeneous membrane vesicles
secreted by cells in extracellular spaces that play an important role in intercellular …
secreted by cells in extracellular spaces that play an important role in intercellular …
Modulation of the p75NTR during adolescent alcohol exposure prevents cholinergic neuronal atrophy and associated acetylcholine activity and behavioral …
Binge alcohol consumption during adolescence can produce lasting deficits in learning and
memory while also increasing the susceptibility to substance use disorders. The adolescent …
memory while also increasing the susceptibility to substance use disorders. The adolescent …
Behavioral flexibility in alcohol‐drinking monkeys: The morning after
TA Shnitko, SW Gonzales, N Newman… - Alcoholism: Clinical …, 2020 - Wiley Online Library
Background Heavy alcohol drinking has aspects of inflexible behavior. This study addressed
the consequences of chronic alcohol drinking on cognitive and sensory‐motor domains of …
the consequences of chronic alcohol drinking on cognitive and sensory‐motor domains of …
Acute depletion of dopamine precursors in the human brain: effects on functional connectivity and alcohol attentional bias
Individuals who abuse alcohol often show exaggerated attentional bias (AB) towards
alcohol-related cues, which is thought to reflect reward conditioning processes. Rodent …
alcohol-related cues, which is thought to reflect reward conditioning processes. Rodent …
Adolescent alcohol exposure persistently alters orbitofrontal cortical encoding of Pavlovian conditional stimulus components in female rats
Exposure to alcohol during adolescence impacts cortical and limbic brain regions
undergoing maturation. In rodent models, long-term effects on behavior and …
undergoing maturation. In rodent models, long-term effects on behavior and …