[HTML][HTML] Spaceflight associated neuro-ocular syndrome (SANS) and the neuro-ophthalmologic effects of microgravity: a review and an update

AG Lee, TH Mader, CR Gibson, W Tarver, P Rabiei… - npj …, 2020 - nature.com
Prolonged microgravity exposure during long-duration spaceflight (LDSF) produces unusual
physiologic and pathologic neuro-ophthalmic findings in astronauts. These microgravity …

Neuro-consequences of the spaceflight environment

SD Mhatre, J Iyer, S Puukila, AM Paul… - Neuroscience & …, 2022 - Elsevier
As human space exploration advances to establish a permanent presence beyond the Low
Earth Orbit (LEO) with NASA's Artemis mission, researchers are striving to understand and …

Brain ventricular volume changes induced by long-duration spaceflight

A Van Ombergen, S Jillings… - Proceedings of the …, 2019 - National Acad Sciences
Long-duration spaceflight induces detrimental changes in human physiology. Its residual
effects and mechanisms remain unclear. We prospectively investigated the changes in …

Optic disc edema and choroidal engorgement in astronauts during spaceflight and individuals exposed to bed rest

SS Laurie, SMC Lee, BR Macias, N Patel… - JAMA …, 2020 - jamanetwork.com
Importance Optic disc edema develops in astronauts during long-duration spaceflight and is
a risk for all future astronauts during spaceflight. Having a ground-based analogue of …

Prolonged microgravity affects human brain structure and function

DR Roberts, D Asemani, PJ Nietert… - American Journal …, 2019 - Am Soc Neuroradiology
BACKGROUND AND PURPOSE: Widespread brain structural changes are seen following
extended spaceflight missions. The purpose of this study was to investigate whether these …

Space medicine in the era of civilian spaceflight

J Stepanek, RS Blue, S Parazynski - New England Journal of …, 2019 - Mass Medical Soc
Medical Issues in Civilian Spaceflight As space travel expands to include civilian
populations in addition to trained astronauts, physicians and space medicine experts will …

[HTML][HTML] Comprehensive assessment of physiological responses in women during the ESA dry immersion VIVALDI microgravity simulation

A Robin, A Van Ombergen, C Laurens… - Nature …, 2023 - nature.com
Astronauts in microgravity experience multi-system deconditioning, impacting their inflight
efficiency and inducing dysfunctions upon return to Earth gravity. To fill the sex gap of …

Gravitational dose‐response curves for acute cardiovascular hemodynamics and autonomic responses in a tilt paradigm

RS Whittle, N Keller, EA Hall, HS Vellore… - Journal of the …, 2022 - Am Heart Assoc
Background The cardiovascular system is strongly dependent on the gravitational
environment. Gravitational changes cause mechanical fluid shifts and, in turn, autonomic …

[HTML][HTML] Health challenges including behavioral problems in long-duration spaceflight

CR Doarn, JD Polk, M Shepanek - Neurology India, 2019 - journals.lww.com
Over the past 60 years, our ability to live and work in space has evolved. From short
sojourns in small spacecraft to landing on the moon and residing in an orbiting international …

Spaceflight associated neuro-ocular syndrome (SANS): an update on potential microgravity-based pathophysiology and mitigation development

J Ong, TH Mader, CR Gibson, SS Mason, AG Lee - Eye, 2023 - nature.com
Long-duration spaceflight is associated with neurologic and ophthalmic clinical and imaging
findings in astronauts termed spaceflight associated neuro-ocular syndrome (SANS). These …