Mental disorders are a significant cause of disability worldwide. They profoundly affect
individuals' well-being and impose a substantial financial burden on societies and …

The scientific community is increasingly concerned with the proportion of published
“discoveries” that are not replicated in subsequent studies. The field of rodent behavioral …

Worldwide medicinal use of cannabis is rapidly escalating, despite limited evidence of its
efficacy from preclinical and clinical studies. Here we show that cannabidiol (CBD) …

Measuring Behaviour is the established go-to text for anyone interested in scientific methods
for studying the behaviour of animals or humans. It is widely used by students, teachers and …

Transgenic Tg2576 mice overexpressing human amyloid precursor protein (hAPP) are a
widely used Alzheimer's disease (AD) mouse model to evaluate treatment effects on amyloid …

Aging is characterized by a general decline in cellular function, which ultimately will affect
whole body homeostasis. Although DNA damage and oxidative stress all contribute to …

Handling laboratory animals during test procedures is an important source of stress that may
impair reliability of test responses. Picking up mice by the tail is aversive, stimulating stress …

The reproducibility crisis (or replication crisis) in biomedical research is a particularly
existential and under-addressed issue in the field of behavioral neuroscience, where, in …

Light–dark box and open field are conventional tests for assessment of anxiety-like behavior
in the laboratory mice, based on approach–avoidance conflict. However, except the basic …

It is widely believed that environmental standardization is the best way to guarantee
reproducible results in animal experiments. However, mounting evidence indicates that …