Three-dimensional protein structure prediction: Methods and computational strategies

M Dorn, MB e Silva, LS Buriol, LC Lamb - Computational biology and …, 2014 - Elsevier
A long standing problem in structural bioinformatics is to determine the three-dimensional (3-
D) structure of a protein when only a sequence of amino acid residues is given. Many …

A3N: an artificial neural network n-gram-based method to approximate 3-D polypeptides structure prediction

M Dorn, ON De Souza - Expert Systems with Applications, 2010 - Elsevier
A long standing problem in computational molecular biology is to determine the three-
dimensional (3-D) structure of a protein when only a sequence of amino acids residues is …

A knowledge-based genetic algorithm to predict three-dimensional structures of polypeptides

M Dorn, M Inostroza-Ponta, LS Buriol… - 2013 IEEE Congress …, 2013 - ieeexplore.ieee.org
Three-dimensional (3-D) protein structure determination has become an important area of
research in structural bioinformatics. Proteins are responsible for the execution of different …

Mining the protein data bank with cref to predict approximate 3-d structures of polypeptides

M Dorn, ON De Souza - International Journal of Data Mining …, 2010 - inderscienceonline.com
In this paper we describe CReF, a Central Residue Fragmentbased method to predict
approximate 3-D structures of polypeptides by mining the Protein Data Bank (PDB). The …

An expert protein loop refinement protocol by molecular dynamics simulations with restraints

KCM Dall'Agno, ON de Souza - Expert systems with applications, 2013 - Elsevier
Protein structure prediction (PSP) is a long standing problem in structural biology and
bioinformatics. Within the PSP problem loop refinement is a major bottleneck. In this article …

A molecular dynamics and knowledge-based computational strategy to predict native-like structures of polypeptides

M Dorn, LS Buriol, LC Lamb - Expert systems with applications, 2013 - Elsevier
One of the main research problems in structural bioinformatics is the prediction of three-
dimensional structures (3-D) of polypeptides or proteins. The current rate at which amino …

An interval-based algorithm to represent conformational states of experimentally determined polypeptide templates and fast prediction of approximated 3D protein …

M Dorn, O Norberto de Souza - International Journal of …, 2013 - inderscienceonline.com
Predicting the three-dimensional (3-D) structure of a protein that has no templates in the
Protein Data Bank (PDB) is a very hard, still an impossible task. Computational prediction …

Comparaison de surface épitopiques en fonction de différentes conditions et calculs d'affinité protéine-protéine par méthodes bio-informatiques

L Berthier - 2021 - theses.hal.science
La vaccination est l'outil de choix pour illustrer l'adage «mieux vaut prévenir que guérir». Le
mode de fonctionnement est simple, elle consiste à exposer l'organisme à un ou plusieurs …

[PDF][PDF] Predição da estrutura 3D de proteínas mimetizando o ambiente ribossômico

CE Sequeiros Borja - 2017 - repositorio.pucrs.br
A predição de estrutura 3D de proteínas partindo apenas da sequência de aminoácidos
ainda é um grande desafio em bioinformática estrutural. Apesar da dificuldade, a predição …

Apport de la modélisation et des simulations de dynamique moléculaire à la description de STAT5 comme cible pour moduler la signalisation oncogénique

F Langenfeld - 2015 - theses.hal.science
STAT5 est une protéine de la signalisation cellulaire normale, qui peut jouer un rôle
important dans la transformation, la survie et à la résistance aux inhibiteurs de tyrosine …