This review summarizes knowledge concerning a ubiquitous plasma transmembraneprotein
family that mediates nucleobase or ascorbate secondary active transport (NAT). We show …

Early genetic and physiological work in bacteria and fungi has suggested the presence of
highly specific nucleobase transport systems. Similar transport systems are now known to …

Transporters are ubiquitous proteins mediating the translocation of solutes across cell
membranes, a biological process involved in nutrition, signaling, neurotransmission, cell …

The coding potential of the genome of E. coli K-12 includes YgfO and YicE, two members of
the evolutionarily conserved NAT/NCS2 transporter family that are highly homologous to …

Transporters are transmembrane proteins mediating the selective uptake or efflux of solutes,
metabolites, drugs, or ions across cellular membranes. Despite their immense biological …

UapA, a member of the NAT/NCS2 family, is a high affinity, high capacity, uric acid-
xanthine/H+ symporter of Aspergillus nidulans. We have previously presented evidence …

The azgA gene of Aspergillus nidulans encodes a hypoxanthine-adenine-guanine
transporter. It has been cloned by a novel transposon methodology. The null phenotype of …

Salvage pathways play an important role in providing nucleobases to cells, which are
unable to synthesize sufficient amounts for their needs. Cellular uptake systems for …

In plants, nucleobase biochemistry is highly compartmented relying upon a well-regulated
and selective membrane transport system. In Arabidopsis two proteins, AtAzg1 and AtAzg2 …

In this article we study the cellular expression of UapA and AzgA, the two major purine
transporters of Aspergillus nidulans, by constructing strains expressing, from their native …