Beyond the emerging field of oncological ultrasound molecular imaging, the recent
significant advancements in ultrasound and contrast agent technology have paved the way …

Bone loss associated with fracture nonunion, revision total joint arthroplasty (TJA), and
pseudoarthrosis of the spine presents a challenging clinical scenario for the orthopaedic …

More than 2 million bone-grafting procedures are performed each year using autografts or
allografts. However, both options carry disadvantages, and there remains a clear medical …

Viral carrier transport efficiency of gene delivery is high, depending on the type of vector.
However, viral delivery poses significant safety concerns such as inefficient/unpredictable …

Genes can be transferred using viral or non-viral vectors. Non-viral methods that use
plasmid DNA and short interference RNA (siRNA) have advantages, such as low …

Autografting, a major treatment for bone fractures, has potential risks related to the required
surgery and disease transmission. Bone morphogenetic proteins (BMPs) are the most …

Despite its introduction more than three decades ago, gene therapy has fallen short of its
expected potential for the treatment of a broad spectrum of diseases and continues to lack …

Bone has an intrinsic healing capacity that may be exceeded when the fracture gap is too
big or unstable. In that moment, osteogenic measures need to be taken by physicians. It is …

Abstract Purpose of Review The purpose of this review is to discuss the recent advances in
gene therapy as a treatment for bone regeneration. While most fractures heal …

Bone grafts are medical devices that are in high demand in clinical practice for substitution
of bone defects and recovery of atrophic bone regions. Based on the analysis of the modern …