Integrated lncRNA function upon genomic and epigenomic regulation
Although some long noncoding (lnc) RNAs are known since the 1950s, the past 25 years
have uncovered myriad lncRNAs with diverse sequences, structures, and functions. The …
have uncovered myriad lncRNAs with diverse sequences, structures, and functions. The …
LNCcation: lncRNA localization and function
MC Bridges, AC Daulagala, A Kourtidis - Journal of Cell Biology, 2021 - rupress.org
Subcellular localization of RNAs has gained attention in recent years as a prevalent
phenomenon that influences numerous cellular processes. This is also evident for the large …
phenomenon that influences numerous cellular processes. This is also evident for the large …
[HTML][HTML] Human brown adipocyte thermogenesis is driven by β2-AR stimulation
DP Blondin, S Nielsen, EN Kuipers, MC Severinsen… - Cell metabolism, 2020 - cell.com
Stimulation of brown adipose tissue (BAT) thermogenesis in humans has emerged as an
attractive target to improve metabolic health. Pharmacological stimulations targeting the β 3 …
attractive target to improve metabolic health. Pharmacological stimulations targeting the β 3 …
The evolving view of thermogenic adipocytes—ontogeny, niche and function
The worldwide incidence of obesity and its sequelae, such as type 2 diabetes mellitus, have
reached pandemic levels. Central to the development of these metabolic disorders is …
reached pandemic levels. Central to the development of these metabolic disorders is …
An update on brown adipose tissue biology: a discussion of recent findings
Brown adipose tissue (BAT) has been encouraged as a potential treatment for obesity and
comorbidities due to its thermogenic activity capacity and contribution to energy expenditure …
comorbidities due to its thermogenic activity capacity and contribution to energy expenditure …
LncRNA-mediated adipogenesis in different adipocytes
P Zhang, S Wu, Y He, X Li, Y Zhu, X Lin… - International Journal of …, 2022 - mdpi.com
Long-chain noncoding RNAs (lncRNAs) are RNAs that do not code for proteins, widely
present in eukaryotes. They regulate gene expression at multiple levels through different …
present in eukaryotes. They regulate gene expression at multiple levels through different …
The lncRNA HOXA11os regulates mitochondrial function in myeloid cells to maintain intestinal homeostasis
This study reveals a previously uncharacterized mechanism to restrict intestinal
inflammation via a regulatory RNA transcribed from a noncoding genomic locus. We …
inflammation via a regulatory RNA transcribed from a noncoding genomic locus. We …
CRISPR-enhanced human adipocyte browning as cell therapy for metabolic disease
E Tsagkaraki, SM Nicoloro, T DeSouza… - Nature …, 2021 - nature.com
Obesity and type 2 diabetes are associated with disturbances in insulin-regulated glucose
and lipid fluxes and severe comorbidities including cardiovascular disease and …
and lipid fluxes and severe comorbidities including cardiovascular disease and …
LncRNAs in cancer: from garbage to junk
Simple Summary Long non-coding RNAs (lncRNAs) are generally defined as transcripts
longer than 200 nucleotides and not coding for proteins. This review provides an overview of …
longer than 200 nucleotides and not coding for proteins. This review provides an overview of …