After maternal predetermination gives way to zygotic regulation, a ground state is
established within the mammalian embryo. This tabula rasa for embryogenesis is present …

▪ Abstract Mouse embryonic stem cells are continuous cell lines derived directly from the
fetal founder tissue of the preimplantation embryo. They can be expanded in culture while …

Naive pluripotency is manifest in the preimplantation mammalian embryo. Here we
determine transcriptome dynamics of mouse development from the eight-cell stage to …

Oct4 is a mammalian POU transcription factor expressed by early embryo cells and germ
cells. We report that the activity of Oct4 is essential for the identity of the pluripotential …

Cell fate during development is defined by transcription factors that act as molecular
switches to activate or repress specific gene expression programmes. The POU transcription …

Embryonic stem (ES) cells derived from the inner cell mass (ICM) of blastocysts grow
infinitely while maintaining pluripotency. Leukemia inhibitory factor (LIF) can maintain self …

Each cell lineage specified in the preimplantation mammalian embryo depends on intrinsic
factors for its development, but there is also mutual interdependence between them. OCT4 is …

Pluripotency is generated naturally during mammalian development through formation of the
epiblast, founder tissue of the embryo proper. Pluripotency can be recreated by somatic cell …

Outside cells of the preimplantation mouse embryo form the trophectoderm (TE), a process
requiring the transcription factor Tead4. Here, we show that transcriptionally active Tead4 …

The trophoblast cell lineage is essential for the survival of the mammalian embryo in utero.
This lineage is specified before implantation into the uterus and is restricted to form the fetal …