The modularity and synthetic flexibility of metal–organic frameworks (MOFs) have provoked
analogies with enzymes, and even the term MOFzymes has been coined. In this review, we …

Millions of years of evolution have produced biological systems capable of efficient one-pot
multi-step catalysis. The underlying mechanisms that facilitate these reaction processes are …

Tunnels and channels facilitate the transport of small molecules, ions and water solvent in a
large variety of proteins. Characteristics of individual transport pathways, including their …

MOLEonline is an interactive, web-based application for the detection and characterization
of channels (pores and tunnels) within biomacromolecular structures. The updated version …

How cells sense and respond to environmental cues remains a central question of biological
research. Recent evidence suggests that DNA transcription is regulated by chromatin …

Enzymes can perform complex multistep cascade reactions by linking multiple distinct
catalytic sites via substrate channeling. We mimic this feature in a generalized approach …

Thiamine diphosphate (ThDP) is used as a cofactor in many key metabolic enzymes. We
present evidence that the ThDPs in the two active sites of the E1 (EC 1.2. 4.1) component of …

We present a quantitative model to demonstrate that coclustering multiple enzymes into
compact agglomerates accelerates the processing of intermediates, yielding the same …

With the elucidation of myriad anabolic and catabolic enzyme-catalyzed cellular pathways
crisscrossing each other, an obvious question arose: how could these networks operate with …

Enzymes are biocatalysts that speed up the reactions taking place inside the cell. They are
widely used in industries, scientific research and clinical diagnostics. Enzymes are specific …