The mechanisms and functions of synaptic facilitation
SL Jackman, WG Regehr - Neuron, 2017 - cell.com
The ability of the brain to store and process information relies on changing the strength of
connections between neurons. Synaptic facilitation is a form of short-term plasticity that …
connections between neurons. Synaptic facilitation is a form of short-term plasticity that …
[HTML][HTML] MicroScale Thermophoresis: Interaction analysis and beyond
M Jerabek-Willemsen, T André, R Wanner… - Journal of Molecular …, 2014 - Elsevier
MicroScale Thermophoresis (MST) is a powerful technique to quantify biomolecular
interactions. It is based on thermophoresis, the directed movement of molecules in a …
interactions. It is based on thermophoresis, the directed movement of molecules in a …
Phosphoinositides: tiny lipids with giant impact on cell regulation
T Balla - Physiological reviews, 2013 - journals.physiology.org
Phosphoinositides (PIs) make up only a small fraction of cellular phospholipids, yet they
control almost all aspects of a cell's life and death. These lipids gained tremendous research …
control almost all aspects of a cell's life and death. These lipids gained tremendous research …
[HTML][HTML] Microscale thermophoresis quantifies biomolecular interactions under previously challenging conditions
SAI Seidel, PM Dijkman, WA Lea, G van den Bogaart… - Methods, 2013 - Elsevier
Microscale thermophoresis (MST) allows for quantitative analysis of protein interactions in
free solution and with low sample consumption. The technique is based on thermophoresis …
free solution and with low sample consumption. The technique is based on thermophoresis …
The myosin mesa and the basis of hypercontractility caused by hypertrophic cardiomyopathy mutations
Hypertrophic cardiomyopathy (HCM) is primarily caused by mutations in β-cardiac myosin
and myosin-binding protein-C (MyBP-C). Changes in the contractile parameters of myosin …
and myosin-binding protein-C (MyBP-C). Changes in the contractile parameters of myosin …
Synaptotagmin 1-triggered lipid signaling facilitates coupling of exo-and endocytosis
S Bolz, N Kaempf, D Puchkov, M Krauss, G Russo… - Neuron, 2023 - cell.com
Exocytosis and endocytosis are essential physiological processes and are of prime
importance for brain function. Neurotransmission depends on the Ca 2+-triggered …
importance for brain function. Neurotransmission depends on the Ca 2+-triggered …
Phosphatidylinositol 4, 5-bisphosphate clusters act as molecular beacons for vesicle recruitment
A Honigmann, G Van Den Bogaart, E Iraheta… - Nature structural & …, 2013 - nature.com
Synaptic-vesicle exocytosis is mediated by the vesicular Ca2+ sensor synaptotagmin-1.
Synaptotagmin-1 interacts with the SNARE protein syntaxin-1A and acidic phospholipids …
Synaptotagmin-1 interacts with the SNARE protein syntaxin-1A and acidic phospholipids …
[HTML][HTML] Signaling through C2 domains: more than one lipid target
S Corbalan-Garcia, JC Gómez-Fernández - Biochimica et Biophysica Acta …, 2014 - Elsevier
C2 domains are membrane-binding modules that share a common overall fold: a single
compact Greek-key motif organized as an eight-stranded anti-parallel β-sandwich consisting …
compact Greek-key motif organized as an eight-stranded anti-parallel β-sandwich consisting …
Parkinson's disease-associated LRRK2 hyperactive kinase mutant disrupts synaptic vesicle trafficking in ventral midbrain neurons
Parkinson's disease (PD) is characterized pathologically by the selective loss of substantia
nigra (SN) dopaminergic (DAergic) neurons. Recent evidence has suggested a role of …
nigra (SN) dopaminergic (DAergic) neurons. Recent evidence has suggested a role of …
Thermophoresis for characterizing biomolecular interaction
The study of biomolecular interactions is crucial to get more insight into the biological
system. The interactions of protein-protein, protein-nucleic acids, protein-sugars, nucleic …
system. The interactions of protein-protein, protein-nucleic acids, protein-sugars, nucleic …