The T-box gene family: emerging roles in development, stem cells and cancer
VE Papaioannou - Development, 2014 - journals.biologists.com
The T-box family of transcription factors exhibits widespread involvement throughout
development in all metazoans. T-box proteins are characterized by a DNA-binding motif …
development in all metazoans. T-box proteins are characterized by a DNA-binding motif …
The roles and regulation of TBX3 in development and disease
TBX3, a member of the ancient and evolutionary conserved T-box transcription factor family,
is a critical developmental regulator of several structures including the heart, mammary …
is a critical developmental regulator of several structures including the heart, mammary …
T-box transcription factors in cancer biology
S Wansleben, J Peres, S Hare, CR Goding… - Biochimica et Biophysica …, 2014 - Elsevier
The evolutionarily conserved T-box family of transcription factors have critical and well-
established roles in embryonic development. More recently, T-box factors have also gained …
established roles in embryonic development. More recently, T-box factors have also gained …
TBX3 promotes progression of pre‐invasive breast cancer cells by inducing EMT and directly up‐regulating SLUG
The acquisition of cellular invasiveness by breast epithelial cells and subsequent transition
from ductal carcinoma in situ (DCIS) to invasive breast cancer is a critical step in breast …
from ductal carcinoma in situ (DCIS) to invasive breast cancer is a critical step in breast …
The chromatin remodeler Chd4 maintains embryonic stem cell identity by controlling pluripotency-and differentiation-associated genes
H Zhao, Z Han, X Liu, J Gu, F Tang, G Wei… - Journal of Biological …, 2017 - ASBMB
The unique properties of embryonic stem cells (ESCs), including unlimited self-renewal and
pluripotent differentiation potential, are sustained by integrated genetic and epigenetic …
pluripotent differentiation potential, are sustained by integrated genetic and epigenetic …
The T-Box transcription factor 3 in development and cancer
T-box factors comprise an archaic family of evolutionary conserved transcription factors that
regulate patterns of gene expression essential for embryonic development. The T-box …
regulate patterns of gene expression essential for embryonic development. The T-box …
The special stemness functions of Tbx3 in stem cells and cancer development
The T-box factors belong to an ancient protein family, which comprises a cluster of
evolutionarily-conserved transcription factors that regulate gene expression and that are …
evolutionarily-conserved transcription factors that regulate gene expression and that are …
hnRNPLL controls pluripotency exit of embryonic stem cells by modulating alternative splicing of Tbx3 and Bptf
X Wang, C Ping, P Tan, C Sun, G Liu, T Liu… - The EMBO …, 2021 - embopress.org
The regulatory circuitry underlying embryonic stem (ES) cell self‐renewal is well defined, but
how this circuitry is disintegrated to enable lineage specification is unclear. RNA‐binding …
how this circuitry is disintegrated to enable lineage specification is unclear. RNA‐binding …
Derivation of induced pluripotent stem cells from ferret somatic cells
Ferrets are an attractive mammalian model for several diseases, especially those affecting
the lungs, liver, brain, and kidneys. Many chronic human diseases have been difficult to …
the lungs, liver, brain, and kidneys. Many chronic human diseases have been difficult to …
Putative Breast Cancer Driver Mutations in TBX3 Cause Impaired Transcriptional Repression
K Fischer, GO Pflugfelder - Frontiers in oncology, 2015 - frontiersin.org
The closely related T-box transcription factors TBX2 and TBX3 are frequently overexpressed
in melanoma and various types of human cancers, in particular, breast cancer. The …
in melanoma and various types of human cancers, in particular, breast cancer. The …