Current and next-generation formulation strategies for inactivated polio vaccines to lower costs, increase coverage, and facilitate polio eradication

P Kumar, C Bird, D Holland, SB Joshi… - Human Vaccines & …, 2022 - Taylor & Francis
Implementation of inactivated polio vaccines (IPV) containing Sabin strains (sIPV) will further
enable global polio eradication efforts by improving vaccine safety during use and …

[HTML][HTML] Concordance of in vitro and in vivo measures of non-replicating rotavirus vaccine potency

D McAdams, M Estrada, D Holland, J Singh, N Sawant… - Vaccine, 2022 - Elsevier
Rotavirus infections remain a leading cause of morbidity and mortality among infants
residing in low-and middle-income countries. To address the large need for protection from …

Thermostable, dissolvable buccal film rotavirus vaccine is highly effective in neonatal gnotobiotic pig challenge model

C Hensley, P Zhou, S Schnur, HM Mahsoub, Y Liang… - Vaccines, 2021 - mdpi.com
Difficulties related to storage and transport of currently available live oral rotavirus vaccines
can have detrimental consequences on the efficacy of the vaccines. Thus, there is a great …

[HTML][HTML] Formulation studies to develop low-cost, orally-delivered secretory IgA monoclonal antibodies for passive immunization against enterotoxigenic Escherichia …

S Bajoria, LR Antunez, OS Kumru, M Klempner… - Journal of …, 2023 - Elsevier
Enterotoxigenic Escherichia coli (ETEC) is a common cause for diarrheal infections in
children in low-and middle-income countries (LMICs). To date, no ETEC vaccine candidates …

Evaluating the Compatibility of New Recombinant Protein Antigens (Trivalent NRRV) with a Mock Pentavalent Combination Vaccine Containing Whole-Cell Pertussis …

P Kumar, DA Holland, K Secrist, P Taskar, B Dotson… - Vaccines, 2024 - mdpi.com
Introducing new recombinant protein antigens to existing pediatric combination vaccines is
important in improving coverage and affordability, especially in low-and middle-income …

[HTML][HTML] Modeling the long-term 2-8 C stability profiles of a live, rotavirus vaccine candidate (RV3-BB) in various liquid formulations via extrapolations of real-time and …

SR Pullagurla, P Kumar, O Ogun, OS Kumru, A Hamidi… - Biologicals, 2022 - Elsevier
To accelerate the formulation development of live-virus vaccine (LVV) candidates, more
rapid approaches to rank-order formulations and estimate their real-time storage stability …

[HTML][HTML] Evaluating the Compatibility of Three Aluminum Salt-Adjuvanted Recombinant Protein Antigens (Trivalent NRRV) Combined with a Mock Trivalent Sabin-IPV …

P Kumar, A Hamana, C Bird, B Dotson… - Vaccines, 2024 - mdpi.com
In this work, we describe compatibility assessments of a recombinant, trivalent non-
replicating rotavirus vaccine (t-NRRV) candidate with a mock trivalent Sabin inactivated …

Formulation development of a live attenuated human rotavirus (RV3-BB) vaccine candidate for use in low-and middle-income countries

P Kumar, RS Shukla, A Patel… - Human Vaccines & …, 2021 - Taylor & Francis
Formulation development was performed with the live, attenuated, human neonatal rotavirus
vaccine candidate (RV3-BB) with three main objectives to facilitate use in low-and middle …

[HTML][HTML] Developing a manufacturing process to deliver a cost effective and stable liquid human rotavirus vaccine

A Hamidi, F Hoeksema, P Velthof, A Lemckert… - Vaccine, 2021 - Elsevier
Despite solid evidence of the success of rotavirus vaccines in saving children from fatal
gastroenteritis, more than 82 million infants worldwide still lack access to a rotavirus vaccine …

In Vitro Stability and in Vivo Performance Considerations to Develop Low-Cost Recombinant Protein Formulations for Passive and Active Immunization

S Bajoria - 2023 - search.proquest.com
Low-cost and affordable vaccines and biotherapeutics will allow for more equitable global
distribution and improve population coverage, especially in low-and middle-income …