Ammonia metabolism and hyperammonemic disorders

V Walker - Advances in clinical chemistry, 2014 - Elsevier
Human adults produce around 1000 mmol of ammonia daily. Some is reutilized in
biosynthesis. The remainder is waste and neurotoxic. Eventually most is excreted in urine as …

Virulence regulation of phytopathogenic fungi by pH

N Alkan, EA Espeso, D Prusky - Antioxidants & Redox Signaling, 2013 - liebertpub.com
Significance: Postharvest pathogens can start its attack process immediately after spores
land on wounded tissue, whereas other pathogens can forcibly breach the unripe fruit cuticle …

Ameliorative effect of oregano (Origanum vulgare) versus silymarin in experimentally induced hepatic encephalopathy

EAR Abdelghffar, HAS El-Nashar, S Fayez… - Scientific Reports, 2022 - nature.com
Hepatic encephalopathy (HE) is a deterioration of brain function in patients suffering from
chronic liver disease, cirrhosis as a result of elevated blood ammonia and the production of …

Ursolic Acid Attenuates D-Galactose-Induced Inflammatory Response in Mouse Prefrontal Cortex through Inhibiting AGEs/RAGE/NF-κB Pathway Activation

J Lu, D Wu, Y Zheng, B Hu, Z Zhang, Q Ye… - Cerebral …, 2010 - academic.oup.com
Evidence shows that administration of d-galactose (d-gal) induces reactive oxygen species
(ROS) production and inflammatory response resulting in neurodegenerative changes …

Effect of Boswellia serrata on Antioxidant Status in an Experimental Model of Colitis Rats Induced by Acetic Acid

RM Hartmann, MI Morgan Martins, J Tieppo… - Digestive diseases and …, 2012 - Springer
Abstract Aim of the Study To evaluate the antioxidant effect of an extract of the plant
Boswellia serrata in an experimental model of acute ulcerative colitis induced by …

Systemic oxidative stress is implicated in the pathogenesis of brain edema in rats with chronic liver failure

CR Bosoi, X Yang, J Huynh, C Parent-Robitaille… - Free Radical Biology …, 2012 - Elsevier
Chronic liver failure leads to hyperammonemia, a central component in the pathogenesis of
hepatic encephalopathy (HE); however, a correlation between blood ammonia levels and …

Protective role of antioxidants on thioacetamide-induced acute hepatic encephalopathy: biochemical and ultrastructural study

HN Mustafa, SA El Awdan, GA Hegazy - Tissue and Cell, 2013 - Elsevier
Thioacetamide (TAA) has been used in development of animal models of acute hepatic
encephalopathy (AHE). This experimental study was designed to evaluate effects of oral …

Neurodegenerative signaling factors and mechanisms in Parkinson's pathology

P Goswami, N Joshi, S Singh - Toxicology In Vitro, 2017 - Elsevier
Parkinson's disease (PD) is a chronic and progressive degenerative disorder of central
nervous system which is mainly characterized by selective loss of dopaminergic neurons in …

Effect of Andrographis Paniculata Aqueous Extract on Hyperammonemia Induced Alteration of Oxidative and Nitrosative Stress Factors in the Liver, Spleen and …

A Mukherjee, VP Singh, S Singh - Journal of Herbs, Spices & …, 2024 - Taylor & Francis
Hyperammonemia (HA) can induce oxidative and nitrosative stress in peripheral organs,
potentially exacerbating Hepatic Encephalopathy (HE). This study assessed the efficacy of …

Selective vulnerability of brain regions to oxidative stress in a non-coma model of insulin-induced hypoglycemia

ML Haces, T Montiel, L Massieu - Neuroscience, 2010 - Elsevier
Insulin-induced hypoglycemia causes the death of neurons in particular brain regions
including the cerebral cortex, the striatum and the hippocampus, while the cerebellum and …