CpG and non-CpG methylation in epigenetic gene regulation and brain function

HS Jang, WJ Shin, JE Lee, JT Do - Genes, 2017 - mdpi.com
DNA methylation is a major epigenetic mark with important roles in genetic regulation.
Methylated cytosines are found primarily at CpG dinucleotides, but are also found at non …

The DNA methylation in neurological diseases

S Younesian, AM Yousefi, M Momeny, SH Ghaffari… - Cells, 2022 - mdpi.com
DNA methylation is critical for the normal development and functioning of the human brain,
such as the proliferation and differentiation of neural stem cells, synaptic plasticity, neuronal …

Biomarkers in Parkinson's disease

A Surguchov - … diseases biomarkers: Towards translating research to …, 2022 - Springer
Parkinson's disease (PD) is the second most common neurodegenerative disorder, with a
documented significant increase in its prevalence in the past three decades. Both …

Parkinson's disease is associated with DNA methylation levels in human blood and saliva

YH Chuang, KC Paul, JM Bronstein, Y Bordelon… - Genome medicine, 2017 - Springer
Background Several articles suggest that DNA methylation levels in blood relate to
Parkinson's disease (PD) but there is a need for a large-scale study that involves suitable …

Epigenetic mechanisms of aging and aging-associated diseases

A la Torre, F Lo Vecchio, A Greco - Cells, 2023 - mdpi.com
Aging is an inevitable outcome of life, characterized by a progressive decline in tissue and
organ function. At a molecular level, it is marked by the gradual alterations of biomolecules …

Parkinson's disease-associated, sex-specific changes in DNA methylation at PARK7 (DJ-1), SLC17A6 (VGLUT2), PTPRN2 (IA-2β), and NR4A2 (NURR1) in cortical …

J Kochmanski, NC Kuhn, AI Bernstein - npj Parkinson's Disease, 2022 - nature.com
Evidence for epigenetic regulation playing a role in Parkinson's disease (PD) is growing,
particularly for DNA methylation. Approximately 90% of PD cases are due to a complex …

Dynamic regulation of DNA methylation and brain functions

J Xie, L Xie, H Wei, XJ Li, L Lin - Biology, 2023 - mdpi.com
Simple Summary DNA methylation is involved in biological processes including
neurogenesis, aging, and the pathogenesis of brain disorders by the regulation of gene …

Implications of DNA methylation in Parkinson's disease

E Miranda-Morales, K Meier… - Frontiers in molecular …, 2017 - frontiersin.org
It has been 200 years since Parkinson's disease (PD) was first described, yet many aspects
of its etiopathogenesis remain unclear. PD is a progressive and complex neurodegenerative …

DNA methylation as a mediator of genetic and environmental influences on Parkinson's disease susceptibility: Impacts of alpha-Synuclein, physical activity, and …

SL Schaffner, MS Kobor - Frontiers in genetics, 2022 - frontiersin.org
Parkinson's disease (PD) is a neurodegenerative disorder with a complex etiology and
increasing prevalence worldwide. As PD is influenced by a combination of genetic and …

DNA methylation changes associated with Parkinson's disease progression: outcomes from the first longitudinal genome-wide methylation analysis in blood

A Henderson-Smith, KM Fisch, J Hua, G Liu… - Epigenetics, 2019 - Taylor & Francis
Parkinson's Disease (PD) is a common neurodegenerative disorder currently diagnosed
based on the presentation of characteristic movement symptoms. Unfortunately, patients …