CpG and non-CpG methylation in epigenetic gene regulation and brain function
HS Jang, WJ Shin, JE Lee, JT Do - Genes, 2017 - mdpi.com
DNA methylation is a major epigenetic mark with important roles in genetic regulation.
Methylated cytosines are found primarily at CpG dinucleotides, but are also found at non …
Methylated cytosines are found primarily at CpG dinucleotides, but are also found at non …
The DNA methylation in neurological diseases
DNA methylation is critical for the normal development and functioning of the human brain,
such as the proliferation and differentiation of neural stem cells, synaptic plasticity, neuronal …
such as the proliferation and differentiation of neural stem cells, synaptic plasticity, neuronal …
Biomarkers in Parkinson's disease
A Surguchov - … diseases biomarkers: Towards translating research to …, 2022 - Springer
Parkinson's disease (PD) is the second most common neurodegenerative disorder, with a
documented significant increase in its prevalence in the past three decades. Both …
documented significant increase in its prevalence in the past three decades. Both …
Parkinson's disease is associated with DNA methylation levels in human blood and saliva
YH Chuang, KC Paul, JM Bronstein, Y Bordelon… - Genome medicine, 2017 - Springer
Background Several articles suggest that DNA methylation levels in blood relate to
Parkinson's disease (PD) but there is a need for a large-scale study that involves suitable …
Parkinson's disease (PD) but there is a need for a large-scale study that involves suitable …
Epigenetic mechanisms of aging and aging-associated diseases
A la Torre, F Lo Vecchio, A Greco - Cells, 2023 - mdpi.com
Aging is an inevitable outcome of life, characterized by a progressive decline in tissue and
organ function. At a molecular level, it is marked by the gradual alterations of biomolecules …
organ function. At a molecular level, it is marked by the gradual alterations of biomolecules …
Parkinson's disease-associated, sex-specific changes in DNA methylation at PARK7 (DJ-1), SLC17A6 (VGLUT2), PTPRN2 (IA-2β), and NR4A2 (NURR1) in cortical …
J Kochmanski, NC Kuhn, AI Bernstein - npj Parkinson's Disease, 2022 - nature.com
Evidence for epigenetic regulation playing a role in Parkinson's disease (PD) is growing,
particularly for DNA methylation. Approximately 90% of PD cases are due to a complex …
particularly for DNA methylation. Approximately 90% of PD cases are due to a complex …
Dynamic regulation of DNA methylation and brain functions
J Xie, L Xie, H Wei, XJ Li, L Lin - Biology, 2023 - mdpi.com
Simple Summary DNA methylation is involved in biological processes including
neurogenesis, aging, and the pathogenesis of brain disorders by the regulation of gene …
neurogenesis, aging, and the pathogenesis of brain disorders by the regulation of gene …
Implications of DNA methylation in Parkinson's disease
E Miranda-Morales, K Meier… - Frontiers in molecular …, 2017 - frontiersin.org
It has been 200 years since Parkinson's disease (PD) was first described, yet many aspects
of its etiopathogenesis remain unclear. PD is a progressive and complex neurodegenerative …
of its etiopathogenesis remain unclear. PD is a progressive and complex neurodegenerative …
DNA methylation as a mediator of genetic and environmental influences on Parkinson's disease susceptibility: Impacts of alpha-Synuclein, physical activity, and …
SL Schaffner, MS Kobor - Frontiers in genetics, 2022 - frontiersin.org
Parkinson's disease (PD) is a neurodegenerative disorder with a complex etiology and
increasing prevalence worldwide. As PD is influenced by a combination of genetic and …
increasing prevalence worldwide. As PD is influenced by a combination of genetic and …
DNA methylation changes associated with Parkinson's disease progression: outcomes from the first longitudinal genome-wide methylation analysis in blood
Parkinson's Disease (PD) is a common neurodegenerative disorder currently diagnosed
based on the presentation of characteristic movement symptoms. Unfortunately, patients …
based on the presentation of characteristic movement symptoms. Unfortunately, patients …