It has been nearly three decades since the budding yeast Saccharomyces cerevisiae
became a significant model organism for aging research and it has emerged as both simple …

The structure and organization of cellular membranes have received intense interest,
particularly in investigations of the raft hypothesis. The vast majority of these investigations …

In recent years, the role of sphingolipids in pathogenic fungi, in terms of pathogenicity and
resistance to azole drugs, has been a rapidly growing field. This review describes evidence …

While deviations from the optimal phenotype are deleterious, increased variation can
prevent population extinction under severe stresses. Cell division asymmetry is an important …

Seipin is known for its critical role in controlling lipid droplet (LD) assembly at the LD-forming
subdomain of the endoplasmic reticulum (ER). Here, we identified a new function of seipin …

The uptake of cholesterol from the host is closely linked to the proliferation of pathogenic
fungi and protozoa during infection. For some pathogenic fungi, cholesterol uptake is an …

In yeast, aging is widely understood as the decline of physiological function and the
decreasing ability to adapt to environmental changes. Saccharomyces cerevisiae has …

Protein segregation contributes to various cellular processes such as polarization,
differentiation, and aging. However, the difficulty in global determination of protein …

Phospholipid biosynthesis plays a role in mediating membrane-to-histone communication
that influences metabolic decisions. Upon nutrient deprivation, phospholipid methylation …

Proteostasis declines with age, characterized by the accumulation of unfolded or damaged
proteins. Recent studies suggest that proteins constituting pathological inclusions in …