The structural biology of HIV-1: mechanistic and therapeutic insights
A Engelman, P Cherepanov - Nature Reviews Microbiology, 2012 - nature.com
Three-dimensional molecular structures can provide detailed information on biological
mechanisms and, for cases in which the molecular function affects human health, can …
mechanisms and, for cases in which the molecular function affects human health, can …
HIV-1: fifteen proteins and an RNA
AD Frankel, JAT Young - Annual review of biochemistry, 1998 - annualreviews.org
Human immunodeficiency virus type 1 is a complex retrovirus encoding 15 distinct proteins.
Substantial progress has been made toward understanding the function of each protein, and …
Substantial progress has been made toward understanding the function of each protein, and …
Medicinal chemistry and the molecular operating environment (MOE): application of QSAR and molecular docking to drug discovery
The search for new compounds with a given biological activity requires enormous effort in
terms of manpower and cost. This effort arises from the large number of compounds that …
terms of manpower and cost. This effort arises from the large number of compounds that …
Approaches to the description and prediction of the binding affinity of small‐molecule ligands to macromolecular receptors
The influence of a xenobiotic compound on an organism is usually summarized by the
expression biological activity. If a controlled, therapeutically relevant, and regulatory action …
expression biological activity. If a controlled, therapeutically relevant, and regulatory action …
Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: implications for drug resistance
H Huang, R Chopra, GL Verdine, SC Harrison - Science, 1998 - science.org
A combinatorial disulfide cross-linking strategy was used to prepare a stalled complex of
human immunodeficiency virus–type 1 (HIV-1) reverse transcriptase with a DNA template …
human immunodeficiency virus–type 1 (HIV-1) reverse transcriptase with a DNA template …
Structure and function of HIV-1 reverse transcriptase: molecular mechanisms of polymerization and inhibition
The rapid replication of HIV-1 and the errors made during viral replication cause the virus to
evolve rapidly in patients, making the problems of vaccine development and drug therapy …
evolve rapidly in patients, making the problems of vaccine development and drug therapy …
Functional aptamers and aptazymes in biotechnology, diagnostics, and therapy
Aptamers are single-stranded nucleic acid molecules that possess properties comparable to
those of protein monoclonal antibodies, and thus are clear alternatives to long established …
those of protein monoclonal antibodies, and thus are clear alternatives to long established …
Structural biology of HIV
BG Turner, MF Summers - Journal of molecular biology, 1999 - Elsevier
The human immunodeficiency virus (HIV) genome encodes a total of three structural
proteins, two envelope proteins, three enzymes, and six accessory proteins. Studies over the …
proteins, two envelope proteins, three enzymes, and six accessory proteins. Studies over the …
Implications of protein flexibility for drug discovery
SJ Teague - Nature reviews Drug discovery, 2003 - nature.com
Proteins are in constant motion between different conformational states with similar
energies. This has often been ignored in drug design. However, protein flexibility is …
energies. This has often been ignored in drug design. However, protein flexibility is …
Non-nucleoside reverse transcriptase inhibitors (NNRTIs), their discovery, development, and use in the treatment of HIV-1 infection: a review of the last 20 years (1989 …
MP de Béthune - Antiviral research, 2010 - Elsevier
It is almost 20 years since NNRTIs were identified as a new class of antiretroviral drugs for
the treatment of HIV-1 infection. Although they belong to different and diverse chemical …
the treatment of HIV-1 infection. Although they belong to different and diverse chemical …