Mitochondrial function as a therapeutic target in heart failure

DA Brown, JB Perry, ME Allen, HN Sabbah… - Nature Reviews …, 2017 - nature.com
Heart failure is a pressing worldwide public-health problem with millions of patients having
worsening heart failure. Despite all the available therapies, the condition carries a very poor …

Cardiomyopathy in children: classification and diagnosis: a scientific statement from the American Heart Association

SE Lipshultz, YM Law, A Asante-Korang, ED Austin… - Circulation, 2019 - Am Heart Assoc
In this scientific statement from the American Heart Association, experts in the field of
cardiomyopathy (heart muscle disease) in children address 2 issues: the most current …

Mitochondrial quality control mechanisms as molecular targets in cardiac ageing

A Picca, RT Mankowski, JL Burman, L Donisi… - Nature Reviews …, 2018 - nature.com
Cardiovascular disease is the leading cause of morbidity and mortality worldwide.
Advancing age is a major risk factor for developing cardiovascular disease because of the …

[HTML][HTML] Patient care standards for primary mitochondrial disease: a consensus statement from the Mitochondrial Medicine Society

S Parikh, A Goldstein, A Karaa, MK Koenig, I Anselm… - Genetics in …, 2017 - Elsevier
The purpose of this statement is to provide consensus-based recommendations for optimal
management and care for patients with primary mitochondrial disease. This statement is …

Role of multimodality cardiac imaging in the management of patients with hypertrophic cardiomyopathy: an expert consensus of the European Association of …

N Cardim, M Galderisi, T Edvardsen… - European Heart …, 2015 - academic.oup.com
Taking into account the complexity and limitations of clinical assessment in hypertrophic
cardiomyopathy (HCM), imaging techniques play an essential role in the evaluation of …

The MOGE (S) classification for a phenotype–genotype nomenclature of cardiomyopathy: endorsed by the World Heart Federation

E Arbustini, N Narula, GW Dec, KS Reddy… - Journal of the American …, 2013 - jacc.org
In 1956, Blankerhorn and Gall (1) proposed the term myocarditis for inflammatory heart
muscle disease, and myocardiosis for other heart muscle diseases. A year thereafter …

Exome‐based analysis of cardiac arrhythmia, respiratory control, and epilepsy genes in sudden unexpected death in epilepsy

RD Bagnall, DE Crompton, S Petrovski… - Annals of …, 2016 - Wiley Online Library
Objective The leading cause of epilepsy‐related premature mortality is sudden unexpected
death in epilepsy (SUDEP). The cause of SUDEP remains unknown. To search for genetic …

Whole genome sequencing improves outcomes of genetic testing in patients with hypertrophic cardiomyopathy

RD Bagnall, J Ingles, ME Dinger, MJ Cowley… - Journal of the American …, 2018 - jacc.org
Background: Whole genome sequencing (WGS) is a comprehensive genetic testing
approach that reports most types of nucleotide variants. Objectives: This study sought to …

Pediatric cardiomyopathies

TM Lee, DT Hsu, P Kantor, JA Towbin… - Circulation …, 2017 - Am Heart Assoc
Pediatric cardiomyopathies are rare diseases with an annual incidence of 1.1 to 1.5 per 100
000. Dilated and hypertrophic cardiomyopathies are the most common; restrictive …

[Retracted] Mitochondrial Dysfunction and Cardiovascular Disease: Pathophysiology and Emerging Therapies

CA Stamerra, P Di Giosia, P Giorgini… - Oxidative Medicine …, 2022 - Wiley Online Library
Mitochondria ensure the supply of cellular energy through the production of ATP via
oxidative phosphorylation. The alteration of this process, called mitochondrial dysfunction …