Tumor microenvironment (TME) takes critical roles in tumor resistance to immune checkpoint
inhibitors (ICIs) including anti-programmed death-1 (PD-1) or anti-programmed death-ligand …

Recently, organoid technology has been used to generate a large repository of breast
cancer organoids. Here we present an extensive evaluation of the ability of organoid culture …

Preclinical studies of primary cancer cells are typically done after tumors are removed from
patients or animals at ambient atmospheric oxygen (O2,~ 21%). However, O2 …

Background: Bone is a frequent site of metastases from breast cancer, but existing
therapeutic options are not satisfactory. Although osteoblasts have active roles in cancer …

On 8 December 2022 the organizing committee of the European Network for Breast
Development and Cancer labs (ENBDC) held its fifth annual Think Tank meeting in …

The biologic basis of genetic ancestry-dependent variability in disease incidence and
outcome is just beginning to be explored. We recently reported enrichment of a population of …

Background Genome-wide association studies have identified several breast cancer
susceptibility loci. However, biomarkers for risk assessment are still missing. Here, we …

Study of genomic aberrations leading to immortalization of epithelial cells has been
technically challenging due to the lack of isogenic models. To address this, we used healthy …

Background Family with sequence similarity 83 member A (FAM83A) presents oncogenic
properties in several cancers including breast cancer. Recently, we reported FAM83A …

Abstract Poly (ADP-ribose) polymerase (PARP) inhibitors have emerged as promising
targeted therapies for BRCA-mutated cancers by blocking repair of DNA double-strand …