The organization of cells into interconnected structures such as animal tissues requires a
sophisticated system directing receptors and adhesion proteins to the cell surface. The …

Rabs are GTP-binding proteins with conserved functions in membrane trafficking. They are
regulated by a diverse group of structurally unrelated GDP-GTP exchange factors (GEFs) …

A key requirement for Rab function in membrane trafficking is site-specific activation by GDP-
GTP exchange factors (GEFs), but the majority of the 63 human Rabs have no known GEF …

The DENN domain is a common, evolutionarily ancient, and conserved protein module, yet it
has gone largely unstudied; until recently, little was known regarding its functional roles …

Cell rearrangements shape the Drosophila embryo via spatially regulated changes in cell
shape and adhesion. We show that Bazooka/Par-3 (Baz) is required for the planar polarized …

Gametes are highly specialized cell types produced by a complex differentiation process.
Production of viable oocytes requires a series of precise and coordinated molecular events …

Cancer cells can move through tissues in a variety of different ways. In some cases, an
epithelial-to-mesenchymal transition enables cancer cells to acquire fibroblast-like migratory …

We have identified Rabconnectin-3α and β (Rbcn-3A and B) as two regulators of Notch
signaling in Drosophila. We found that, in addition to disrupting Notch signaling, mutations in …

Epithelial cells have an apical–basolateral axis of polarity, which is required for epithelial
functions including barrier formation, vectorial ion transport and sensory perception. Here …

Basement membranes (BMs) are specialized extracellular matrices that are essential for
epithelial structure and morphogenesis. However, little is known about how BM proteins are …