Although the discovery of the critical role of α-synuclein (α-syn) in the pathogenesis of
Parkinson's disease (PD) is now twenty-five years old, it still represents a milestone in PD …

Abstract α-Synuclein is a neuronal protein that is enriched in presynaptic terminals. Under
physiological conditions, it binds to synaptic vesicle membranes and functions in …

Background Aggregated α-synuclein plays an important role in the pathogenesis of
Parkinson's disease. The monoclonal antibody prasinezumab, directed at aggregated α …

Background Lixisenatide, a glucagon-like peptide-1 receptor agonist used for the treatment
of diabetes, has shown neuroprotective properties in a mouse model of Parkinson's disease …

Almost 2 decades after linking LRRK2 to Parkinson's disease, a vibrant research field has
developed around the study of this gene and its protein product. Recent studies have begun …

Silent information regulator (SIRT) has distinctive enzymatic activities and physiological
functions to control cell-cycle progression, gene expression, and DNA stability by targeting …

Parkinson's disease is a progressive neurodegenerative condition associated with the
deposition of aggregated α-synuclein. Insights into the pathogenesis of Parkinson's disease …

Background Parkinson's disease (PD) is a progressive neurodegenerative disorder
associated with a loss of dopaminergic (DA) neurons. Despite symptomatic therapies, there …

The neurodegenerative synucleinopathies, including Parkinson's disease and dementia
with Lewy bodies, are characterized by a typically lengthy prodromal period of progressive …

Parkinson's disease (PD) is one of the most common degenerative brain disorders caused
by the loss of dopaminergic neurons in the substantia nigra (SN). Lewy bodies and …