A brief review of in vitro models for injury and regeneration in the peripheral nervous system

P Varier, G Raju, P Madhusudanan, C Jerard… - International Journal of …, 2022 - mdpi.com
Nerve axonal injury and associated cellular mechanisms leading to peripheral nerve
damage are important topics of research necessary for reducing disability and enhancing …

Membrane mechanics dictate axonal pearls-on-a-string morphology and function

JM Griswold, M Bonilla-Quintana, R Pepper… - Nature …, 2024 - nature.com
Axons are ultrathin membrane cables that are specialized for the conduction of action
potentials. Although their diameter is variable along their length, how their morphology is …

Microtubule dynamics following central and peripheral nervous system axotomy

R Kulkarni, A Thakur, H Kumar - ACS Chemical Neuroscience, 2022 - ACS Publications
Disturbance in the neuronal network leads to instability in the microtubule (MT) railroad of
axons, causing hindrance in the intra-axonal transport and making it difficult to re-establish …

Onsager's variational principle in active soft matter

H Wang, T Qian, X Xu - Soft Matter, 2021 - pubs.rsc.org
Onsagers variational principle (OVP) was originally proposed by Lars Onsager in 1931 [L.
Onsager, Phys. Rev., 1931, 37, 405]. This fundamental principle provides a very powerful …

Application of Force to a Syndecan-4 Containing Complex With Thy-1–αVβ3 Integrin Accelerates Neurite Retraction

F Burgos-Bravo, S Martínez-Meza… - Frontiers in molecular …, 2020 - frontiersin.org
Inflammation contributes to the genesis and progression of chronic diseases, such as cancer
and neurodegeneration. Upregulation of integrins in astrocytes during inflammation induces …

“Looping in” mechanics: Mechanobiologic regulation of the nucleus and the epigenome

EN Dai, SJ Heo, RL Mauck - Advanced healthcare materials, 2020 - Wiley Online Library
Cells respond to physical cues in their microenvironment. These cues result in changes in
cell behavior, some of which are transient, and others of which are permanent …

Mechanisms of local stress amplification in axons near the gray-white matter interface

F Alisafaei, Z Gong, VE Johnson, JP Dollé, DH Smith… - Biophysical …, 2020 - cell.com
Diffuse axonal injury is a primary neuropathological feature of concussion and is thought to
greatly contribute to the classical symptoms of decreased processing speed and memory …

Generation of contractile forces by three-dimensional bundled axonal tracts in micro-tissue engineered neural networks

D Chouhan, WJ Gordián Vélez, LA Struzyna… - Frontiers in Molecular …, 2024 - frontiersin.org
Axonal extension and retraction are ongoing processes that occur throughout all
developmental stages of an organism. The ability of axons to produce mechanical forces …

The Axonal Actin Filament Cytoskeleton: Structure, Function, and Relevance to Injury and Degeneration

G Gallo - Molecular Neurobiology, 2024 - Springer
Early investigations of the neuronal actin filament cytoskeleton gave rise to the notion that,
although growth cones exhibit high levels of actin filaments, the axon shaft exhibits low …

Fundamental characteristics of neuron adhesion revealed by forced peeling and time-dependent healing

H Liu, C Fang, Z Gong, RCC Chang, J Qian, H Gao… - Biophysical …, 2020 - cell.com
A current bottleneck in the advance of neurophysics is the lack of reliable methods to
quantitatively measure the interactions between neural cells and their microenvironment …