Space radiation biology for “Living in Space”

S Furukawa, A Nagamatsu, M Nenoi… - BioMed Research …, 2020 - Wiley Online Library
Space travel has advanced significantly over the last six decades with astronauts spending
up to 6 months at the International Space Station. Nonetheless, the living environment while …

[HTML][HTML] Behavioral effects of space radiation: A comprehensive review of animal studies

F Kiffer, M Boerma, A Allen - Life sciences in space research, 2019 - Elsevier
As NASA prepares for the first manned mission to Mars in the next 20 years, close attention
has been placed on the cognitive welfare of astronauts, who will likely endure extended …

Cosmic radiation exposure and persistent cognitive dysfunction

VK Parihar, BD Allen, C Caressi, S Kwok, E Chu… - Scientific reports, 2016 - nature.com
The Mars mission will result in an inevitable exposure to cosmic radiation that has been
shown to cause cognitive impairments in rodent models, and possibly in astronauts …

Impact of spaceflight stressors on behavior and cognition: A molecular, neurochemical, and neurobiological perspective

RI Desai, CL Limoli, CEL Stark, SM Stark - Neuroscience & Biobehavioral …, 2022 - Elsevier
The response of the human body to multiple spaceflight stressors is complex, but mounting
evidence implicate risks to CNS functionality as significant, able to threaten metrics of …

Combined effects of three high-energy charged particle beams important for space flight on brain, behavioral and cognitive endpoints in B6D2F1 female and male …

J Raber, J Yamazaki, ERS Torres, N Kirchoff… - Frontiers in …, 2019 - frontiersin.org
The radiation environment in deep space includes the galactic cosmic radiation with
different proportions of all naturally occurring ions from protons to uranium. Most …

Risks of cognitive detriments after low dose heavy ion and proton exposures

FA Cucinotta, E Cacao - International journal of radiation biology, 2019 - Taylor & Francis
Purpose: Heavy ion and proton brain irradiations occur during space travel and in Hadron
therapy for cancer. Heavy ions produce distinct patterns of energy deposition in neuron cells …

Cranial irradiation mediated spine loss is sex-specific and complement receptor-3 dependent in male mice

JJ Hinkle, JA Olschowka, TM Love, JP Williams… - Scientific reports, 2019 - nature.com
Cranial irradiation is the main therapeutic treatment for primary and metastatic malignancies
in the brain. However, cranial radiation therapy produces long-term impairment in memory …

Functional equivalence of stem cell and stem cell-derived extracellular vesicle transplantation to repair the irradiated brain

SM Smith, E Giedzinski, MC Angulo… - Stem cells …, 2020 - academic.oup.com
Cranial radiotherapy, although beneficial for the treatment of brain tumors, inevitably leads
to normal tissue damage that can induce unintended neurocognitive complications that are …

Sex-specific cognitive deficits following space radiation exposure

VK Parihar, MC Angulo, BD Allen, A Syage… - Frontiers in behavioral …, 2020 - frontiersin.org
The radiation fields in space define tangible risks to the health of astronauts, and significant
work in rodent models has clearly shown a variety of exposure paradigms to compromise …

Astrocytes regulate vascular endothelial responses to simulated deep space radiation in a human organ-on-a-chip model

SD Verma, E Passerat de la Chapelle… - Frontiers in …, 2022 - frontiersin.org
Central nervous system (CNS) damage by galactic cosmic ray radiation is a major health
risk for human deep space exploration. Simulated galactic cosmic rays or their components …