EDC-2: the Endocrine Society's second scientific statement on endocrine-disrupting chemicals

AC Gore, VA Chappell, SE Fenton, JA Flaws… - Endocrine …, 2015 - academic.oup.com
Abstract The Endocrine Society's first Scientific Statement in 2009 provided a wake-up call to
the scientific community about how environmental endocrine-disrupting chemicals (EDCs) …

Targeting adipose tissue in the treatment of obesity-associated diabetes

CM Kusminski, PE Bickel, PE Scherer - Nature reviews Drug discovery, 2016 - nature.com
Adipose tissue regulates numerous physiological processes, and its dysfunction in obese
humans is associated with disrupted metabolic homeostasis, insulin resistance and type 2 …

Photoacoustic molecular imaging-escorted adipose photodynamic–browning synergy for fighting obesity with virus-like complexes

R Chen, S Huang, T Lin, H Ma, W Shan, F Duan… - Nature …, 2021 - nature.com
Photodynamic therapy and adipose browning induction are two promising approaches to
reverse obesity. The former strategy acts rapidly and locally, whereas the latter has a more …

Adipose tissue plasticity: how fat depots respond differently to pathophysiological cues

V Pellegrinelli, S Carobbio, A Vidal-Puig - Diabetologia, 2016 - Springer
White adipose tissue (WAT) has key metabolic and endocrine functions and plays a role in
regulating energy homeostasis and insulin sensitivity. WAT is characterised by its capacity to …

Immune regulation of metabolic homeostasis in health and disease

JR Brestoff, D Artis - Cell, 2015 - cell.com
Obesity is an increasingly prevalent disease worldwide. While genetic and environmental
factors are known to regulate the development of obesity and associated metabolic …

Microbiota depletion promotes browning of white adipose tissue and reduces obesity

N Suárez-Zamorano, S Fabbiano, C Chevalier… - Nature medicine, 2015 - nature.com
Brown adipose tissue (BAT) promotes a lean and healthy phenotype and improves insulin
sensitivity. In response to cold or exercise, brown fat cells also emerge in the white adipose …

Heterogeneity of adipose tissue in development and metabolic function

T Schoettl, IP Fischer, S Ussar - Journal of Experimental …, 2018 - journals.biologists.com
Adipose tissue is a central metabolic organ. Unlike other organs, adipose tissue is
compartmentalized into individual depots and distributed throughout the body. These …

MicroRNA regulatory networks in human adipose tissue and obesity

P Arner, A Kulyté - Nature Reviews Endocrinology, 2015 - nature.com
MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression and,
therefore, biological processes in different tissues. A major function of miRNAs in adipose …

Warming induces significant reprogramming of beige, but not brown, adipocyte cellular identity

HC Roh, LTY Tsai, M Shao, D Tenen, Y Shen… - Cell metabolism, 2018 - cell.com
Beige and brown adipocytes generate heat in response to reductions in ambient
temperature. When warmed, both beige and brown adipocytes exhibit morphological" …

The molecular mechanisms of obesity paradox

AS Antonopoulos, D Tousoulis - Cardiovascular research, 2017 - academic.oup.com
Clinical observations suggest a complex relationship between human obesity and
cardiovascular disease. Whilst abdominal (visceral) adiposity leads to deleterious metabolic …