Mucus interaction to improve gastrointestinal retention and pharmacokinetics of orally administered nano-drug delivery systems

DA Subramanian, R Langer, G Traverso - Journal of nanobiotechnology, 2022 - Springer
Oral delivery of therapeutics is the preferred route of administration due to ease of
administration which is associated with greater patient medication adherence. One major …

[HTML][HTML] Designing nanoparticle-based drug delivery systems for precision medicine

J Yang, C Jia, J Yang - International journal of medical sciences, 2021 - ncbi.nlm.nih.gov
Traditional drugs are facing bottlenecks of lower solubility, absorption, and especially the
inefficient organs or cells targeting during the precision medicine era. It is urgently needed to …

Quality by design (QbD) approach in processing polymeric nanoparticles loading anticancer drugs by high pressure homogenizer

G Soni, K Kale, S Shetty, MK Gupta, KS Yadav - Heliyon, 2020 - cell.com
Polymeric nanoparticles prepared using high pressure homogenizer (HPH) present some
unique challenges during manufacturing which can be better understood by application of …

Nanoemulsions: The rising star of antiviral therapeutics and nanodelivery system—Current status and prospects

JS Franklyne, PM Gopinath, A Mukherjee… - Current Opinion in …, 2021 - Elsevier
Nanoemulsions (NEs) of essential oil (EO) have significant potential to target
microorganisms, especially viruses. They act as a vehicle for delivering antiviral drugs and …

The in vivo pharmacokinetics of block copolymers containing polyethylene glycol used in nanocarrier drug delivery systems

L Yin, Y Pang, L Shan, J Gu - Drug Metabolism and Disposition, 2022 - ASPET
Polyethylene glycol (PEG) is one of the most commonly used synthetic macromolecular
polymers for modifying small molecule drugs, peptides, proteins, or nanodrug delivery …

Nanotechnology-based approaches for emerging and re-emerging viruses: special emphasis on COVID-19

M Saravanan, E Mostafavi, S Vincent, H Negash… - Microbial …, 2021 - Elsevier
In recent decades, the major concern of emerging and re-emerging viral diseases has
become an increasingly important area of public health concern, and it is of significance to …

[HTML][HTML] Monocytes as a convergent nanoparticle therapeutic target for cardiovascular diseases

D Aldarondo, E Wayne - Advanced drug delivery reviews, 2022 - Elsevier
Due to the increasing population of individuals with cardiovascular diseases and related
comorbidities, there is an increasing need for development of synergistic therapeutics …

Development and validation of RP-HPLC method for quantification of repaglinide in mPEG-PCL polymeric nanoparticles: QbD-driven optimization, force degradation …

G Wadhwa, KV Krishna, SK Dubey, R Taliyan - Microchemical Journal, 2021 - Elsevier
Repaglinide (REP) an insulinotropic agent used in the treatment of type-2 diabetes. It
belongs to meglitinides, which act by blocking the ATP sensitive potassium channels and …

Nanoparticle-based strategies to target HIV-infected cells

D Soundararajan, LN Ramana, P Shankaran… - Colloids and Surfaces B …, 2022 - Elsevier
Antiretroviral drugs employed for the treatment of human immunodeficiency virus (HIV)
infections have remained largely ineffective due to their poor bioavailability, numerous …

Exploring the potential of intranasally administered naturally occurring quercetin loaded into polymeric nanocapsules as a novel platform for the treatment of anxiety

KY Mahmoud, NA Elhesaisy, AR Rashed… - Scientific Reports, 2023 - nature.com
Anxiety is one of the most prevalent forms of psychopathology that affects millions
worldwide. It gained more importance under the pandemic status that resulted in higher …