Maternal metabolic adaptations during pregnancy ensure appropriate nutrient supply to the
developing fetus. This is facilitated by reductions in maternal peripheral insulin sensitivity …

Intrauterine hypoxia is a feature of pregnancy complications, both at high altitude and sea
level. To understand the placental response to reduced oxygen availability, small animal …

Context Since the initial outbreak of coronavirus disease 2019 (COVID-19), a novel
population of children with in utero exposure to maternal infection has emerged whose …

Incidence of gestational diabetes (GDM) has increased rapidly. It poses significant risks for
both mother and fetus affecting also negatively their longer-term metabolic heath. We asked …

Extreme environmental conditions have profound impacts on shaping the evolutionary
trajectory of organisms. Exposure to these conditions elicits stress responses, that can …

In healthy near-term women, blood flow to the uteroplacental circulation is estimated as 841
mL/min, which is greater than in other mammalian species. We argue that as uterine venous …

Rodent models in rats, mice, and guinea pigs have been extremely helpful to gain insight
into pregnancy physiology and pathologies-related. Moreover, they have allowed …

Abstract High‐altitude (> 2500 m or 8200 ft) residence reduces uterine artery blood flow
during pregnancy, contributing to an increased incidence of preeclampsia and intrauterine …

Key points Pregnancy at high altitude is associated with a greater incidence of fetal growth
restriction due, in part, to lesser uterine artery blood flow. AMP‐activated protein kinase …

Ischemic stroke is one of the most lethal and severely disabling diseases that seriously
affects human health and quality of life. The maintenance of self-renewal and differentiation …