The use of hypoxia models in cell culture has allowed the characterization of the hypoxia
response at the cellular, biochemical and molecular levels. Although a decrease in oxygen …

COVID-19, disease caused by the new coronavirus, SARS-CoV-2, appeared in the end of
2019 and was rapidly spread in most countries. This respiratory virus has different symptoms …

Intracellular signaling pathways are mediated by changes in protein abundance and post-
translational modifications. A common approach for investigating signaling mechanisms and …

Ischemic stroke is caused by insufficient cerebrovascular blood and oxygen supply. It is a
major contributor to death or disability worldwide and has become a heavy societal and …

Adaptation to low oxygen tension (hypoxia) in cells and tissues leads to the transcriptional
induction of a series of genes that participate in angiogenesis, iron metabolism, glucose …

Introduction• Intracellular pH regulation controls energy balance and cell proliferation:
chemical and biological proof of principle‐Chemical proof of principle‐Biological proof of …

Tumour cells emerge as a result of genetic alteration of signal circuitries promoting cell
growth and survival, whereas their expansion relies on nutrient supply. Oxygen limitation is …

BACKGROUND Data from studies conducted in rodent models have shown that decreased
adipose tissue (AT) oxygenation is involved in the pathogenesis of obesity-induced insulin …

SUMOylation is a dynamic process, catalyzed by SUMO-specific ligases and reversed by
Sentrin/SUMO-specific proteases (SENPs). The physiologic consequences of SUMOylation …

Mitogen-activated protein kinase dual-specificity phosphatase-1 (also called MKP-1,
DUSP1, ERP, CL100, HVH1, PTPN10, and 3CH134) is a member of the threonine-tyrosine …