Telomerase reverse transcriptase (TERT) is a catalytic subunit of telomerase. Telomerase
complex plays a key role in cancer formation by telomere dependent or independent …

Autophagy is an important cellular self-digestion and recycling pathway that helps in
maintaining cellular homeostasis. Dysregulation at various steps of the autophagic and …

The increase in available high-throughput molecular data creates computational challenges
for the identification of cancer genes. Genetic as well as non-genetic causes contribute to …

Cell identity is maintained by activation of cell-specific gene programs, regulated by
epigenetic marks, transcription factors and chromatin organization. DNA G-quadruplex (G4) …

Simple Summary O-linked β-N-acetylglucosamine (O-GlcNAc) is a post-translational
modification (PTM) linking nutrient flux through the hexosamine biosynthetic pathway (HBP) …

Background Gemcitabine resistance (GR) is a significant clinical challenge in pancreatic
adenocarcinoma (PAAD) treatment. Macrophages in the tumor immune-microenvironment …

Glucose sensing and metabolic adaptation to glucose availability in the tumor
microenvironment are critical for cancer development. Here we show that HKDC1, a …

Consumption of coffee, tea, wine, curry, and soybeans has been linked to a lower risk of
cancer in epidemiological studies. Several cell-based and animal studies have shown that …

Downregulated expression of anti-tumor miR-383 has been found in many kinds of cancer.
MiR-383 family members can directly target the 3′-untranslated region (3′-UTR) of the …

A global protein interactome ensures the maintenance of regulatory, signaling and structural
processes in cells, but at the same time, aberrations in the repertoire of protein–protein …